Complement

Question 1

true or false: complement can be dangerous to the host

Answer 1

trueeee

Question 2

functions of complement include…

Answer 2

opsonization
phagocyte attraction and activation
bacterial and infected cell lysis 
antibody regulation
clearance of immune complexes and apoptotic cells

Question 3

c-activation

Answer 3

alteration of C proteins so that they interact with the next component

Question 4

c-fixation

Answer 4

Ag-Ab complexes that use complement

Question 5

hemolytic units (CH50)

Answer 5

dilution of serum that lyses 50% of Antibody coated red blood cells

Question 6

c-inactivation

Answer 6

early C-component denaturation which causes loss of hemolytic abilities

Question 7

convertase and esterase

Answer 7

altered C protein that acts as a proteolytic enzyme for another C component

Question 8

What happens to the large and small moiety when a C protein is cleaved

Answer 8

large- binds activation complex, membrane, or pathogen and gains enzymatic activity
small- cleaved and released as soluble signalling molecule

Question 9

what are the three complement pathways

Answer 9

alternative, mannose-binding lection, classical

Question 10

which branch of immunity is the classical pathway and why

Answer 10

adaptive because it employs the use of antibodies

Question 11

what is the main goal of all three complement pathways

Answer 11

create C3b which will cleave C5 and create a membrane attack complex on an infected cell or pathogen

Question 12

why is edema important in an immune response

Answer 12

allows for immune cells to travel more easily