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Complement Pathway Flashcards

0
Q

Cleaves c1s to activate protease function

A

C1r

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1
Q

Binds to antibody that has bound antigen, activates C1r

A

C1q

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2
Q

Cleaves C2 and C4

A

C1s

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3
Q

Unknown function

A

C2a

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4
Q

Activate enzyme of classical pathway

Cleaves C3 and C5

A

C2b

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5
Q

Mediates inflammation

Anaphylatoxin

A

C3a

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6
Q

Binds c5 for cleavage of C2b

Binds cell surfaces for opsonization and activation of alternate pathway

A

C3b

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7
Q

Mediates inflammation

A

C4a

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8
Q

Binds C2 for cleavage by C1s

Bids cell surfaces for opsonization

A

C4b

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9
Q

Mediates inflammation, anaphylotoxin, chemotaxin

A

C5a

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10
Q

Initiates assembly of the membrane attack complex

A

C5b

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11
Q

Binds c5b

Forms receptor for c7

A

C6

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12
Q

Binds c5b6, inserts into membrane, forms acceptor for c8

A

C7

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13
Q

Binds c5b67

Initiates c9 polynerization

A

C8

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14
Q

Polymerizes around c5b678 to form channel that causes cell lysis

A

C9m

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15
Q

Alt Path
Mediates inflammation
Anaphylotoxin

A

C3a

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16
Q

Alt Path

Binds cell surfaces for opsonization and activation of alternate pathway

A

C3b

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17
Q

Alt Path
Bids membrane bound c3b
Cleaved by factor D

A

Factor B-B

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18
Q

Alt Path

Unknown

A

Factor B-Ba

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19
Q

Alt Path

Cleaved form stabilized by P produces c3 convertase

A

Factor B-Bb

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20
Q

Cleaves factor B when bound to c3b

Alt Path

A

Factor D

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21
Q

Binds and stabilizes membrane bound c3bBb

Alt Path

A

Properdin-P

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22
Q

Cleave C2 and C5

Lectin Pathway

A

MASP

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23
Q

Lectin pathway or

A

Mannose binding lectin pathway

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24
Activates C1s
C1r
25
Binds to fc region of IgM and IgG
C1q
26
MASP | Cleaves c4 and c2
MASP 2
27
Central molecule of complement cascade
C3b
28
C3b functions
Opsonizes bacteria | Combines with other complement to generate c5 convertase
29
For opsonization | Enhance phagocytosis
C3b | C1q
30
For chemotaxis | Attracts neutrophils
C5a | C5, 6, 7 complex
31
Enhance adhesiveness of neutrophils to endothelium
C5a
32
Serves as chemoattractants for chemotaxis
C5a
33
Anaphylotoxin
Mast cell | Basophils
34
One of the agents that induces vascular permeability
Histamine
35
Disrupt membrane and entry of water and electrolytes into the cell
Cytolysis MAC
36
Binding of c3b to its receptors on the surface of activated B cells
Enhance ab production
37
Important regulator of classical pathway
C1 INH
38
Serine protease inhibitor/serpin
C1 INH
39
Irreversibly binds to and inactivates c1r and c1s as well as MASP in lectin pathway
C1 INH
40
Regulates alternative pathway
Factor H
41
Reduces amount of c5 convertase available
Factor H
42
Protects c3b and stabilizes c3 convertase
Properdin
43
Cleaves cell bound or fluid phase c3b and c4b | Inactivates c3b and c4b
Factor I
44
Glycoprotein on surface human cells
DAF
45
Prevents assembly of c3bBb or accelerates disassembly of preformed convertase
DAF
46
Cofactor of Factor I
C4b binding protein | C4BP
47
Inhibits the action of c4b in classical pathway
C4BP
48
Splits c4 convertase
C4BP
49
Protectin
CD59
50
Vitronectin
S protein
51
Inhibits formation of MAC by binding c5b678
Protectin and vitronectin
52
Present of self cells to prevent complement from damaging them
Protectin and vitronectin
53
Inhibits MAC formation
Homologous restriction factor
54
Proteolytically cleaves the anaphylotoxins
Anaphylotoxin inhibitor
55
Most severe complement deficiency
Deficiency of c3
56
Deficiency of c5-c8 and mannan binding lectin
Predispose to severe neisseria bacteremia
57
Deficiency of c1 to esterase inhibitor
Angioedema | Inc capillary permeability
58
Paroxysmal nocturnal hemoglobinuria dse
Marcha-fava Mitcheli syndrome
59
Only hemolytic anemia acquired
Paroxysmal nocturnal hemoglobinuria
60
Defect in intrinsic factor which os glycophosphatidyl inositol (red urine)
Paroxysmal nocturnal hemoglobinuria
61
Measures over all complement activity of classical and alternative pathway
CH50 and AH50
62
Measures total classical pathway
CH50

Immunoserology (3 decks)

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