Complementary and Integrative Health

Question 1

• Curcuma longa (ginger family, rhizome)
• phytochemical curcumin- inhibits cyclooxygenase 2, prostaglandins and leukotrienes
• good for Arthritis (OA, RA); LDL reduction in 15-45 year olds and helps with puritis

Answer 1

Tumeric

Question 2

what can St. johns (hypercum perforatum) wort be used for?

Answer 2

depression

• decreased levels of OCPs, clyclosporine, SSRIs
• John’s wort is promoted for depression, menopausal symptoms, attention-deficit hyperactivity disorder (ADHD), somatic symptom disorder (a condition in which a person feels extreme, exaggerated anxiety about physical symptoms), obsessive-compulsive disorder, and other conditions.

Question 3

• Allium sativa
• MOA: cyclooxygenase (thromboxane) vasodilator (NO)
• clinical: HTN, lipids
• Two cloves daily (8-12 weeks is when you start to see the difference)

Answer 3

Garlic

Question 4

• Pestasites hybridus
• rhizomes: EtOH formulations
• pharmacologic activity: petasins (histamin, leukotrienes, other inflammation mediator)
• Good for migraine prophylaxis, Pain & inflammation

Answer 4

butterbur

Question 5

• Currently, promoted as a dietary supplement for urinary symptoms associated with an enlarged prostate gland (also called benign prostatic hyperplasia or BPH), as well as for chronic pelvic pain, migraine, hair loss, and other conditions
• MOA: inhibit 5α-reductase, which is an enzyme responsible for conversion of testosterone to dihydrotestosterone
• headache, nausea, diarrhea, and dizziness have been reported.

Answer 5

Saw Palmetto

Question 6

• Currently promoted as a dietary supplement for hot flashes and other menopausal symptoms. It’s also been promoted for other conditions, including menstrual cramps and premenstrual syndrome, and to induce labor.
• The therapeutic activity of black cohosh was initially believed to be the activation of estrogen receptors; however, more recent studies show that although some components of the extract bind to at least one subtype of estrogen receptor,

Answer 6

Black Cohosh

Question 7

• promoted for sleeplessness, anxiety, and gastrointestinal conditions such as upset stomach, gas, and diarrhea. It is also used topically for skin conditions and for mouth sores resulting from cancer treatment.
• MOA:Chamomile is widely regarded as a mild tranquillizer and sleep-inducer. Sedative effects may be due to the flavonoid, apigenin that binds to benzodiazepine receptors in the brain

Answer 7

chamomile

Question 8

• boost energy, lower blood sugar and cholesterol levels, reduce stress, promote relaxation, treat diabetes, and manage sexual dysfunction in men.
• MOA:stimulatory and inhibitory effects on the nervous system, antineoplastic effects, immunomodulatory effects, and nitric oxide release

Answer 8

Ginseng

Question 9

• various digestive problems including heartburn, intestinal gas, bloating, loss of appetite, and colic in infants. It is also used for upper respiratory tract infections, coughs, bronchitis, cholera, backache, bedwetting, and visual problems
• MOA:comparable to the nonsteroidal antiinflammatory (NSAID) medication, mefenamic acid. The mechanism seems to involve the inhibition of uterine contraction induced by prostaglandin E2 and oxytocin.

Answer 9

Fennel

Question 10

• It also seems to have antibacterial and antifungal effects. People commonly use for anxiety, stress, insomnia, depression, dementia, pain, and many other conditions, but there is no good scientific evidence to support many of these uses.
• MOA: The mechanism of action was postsynaptic and not atropine-like. The spasmolytic effect of lavender oil was most likely to be mediated through cAMP, and not through cGMP.

Answer 10

Lavender