constipation Flashcards

1
Q

common in these 3

A

women
pregnancy
elderly

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2
Q

what is it

A

defecation that is unsatisfactory because of infreq stools, difficult stool passage, seemingly incomplete defection

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3
Q

red flags - malignancy? bowel disorder?

A
  • new onset, esp if >50
  • anaemia, abdominal pain, weight loss, blood in stool
  • review drug if caused by drug
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4
Q

advice for all pt with constipation

A
  • increase dietary fibre (whole grains, fruit, veg)
  • do this gradually to minimise flatulence and bloating
  • effects may be seen in a few days, but may take as long as 4 weeks
  • have fruits high in fibre and sorbitol
  • adequate fluid intake will help soften stool and make it easier to pass
  • this can be difficult in frail and elderly
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5
Q

true or false - avoid fruits that are high in sorbitol and fruit juices high in sorbitol if you have constipation

A

FALSE
e.g. apples, apricots, avocados, cherries, peaches, plums, prunes
These can help prevent and treat constipation

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6
Q

laxative abuse can lead to which electrolyte disturbance?

A

hypokalaemia

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7
Q

name 4 bulk forming laxatives

A

bran
isphagula husk
methyl cellulose
sterculia

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8
Q

this bulk forming laxative also acts as a stool softener

A

methylcellulose

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9
Q

onset of action for bulk forming laxatives

A

up to 72 hours

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10
Q

bulk forming laxatives can exacerbate the following symptoms

A

flatulence, bloating, cramping

(hence why when you counsel pt to increase fibre intake, you advice them to do this gradually)

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11
Q

is it important to advice pt to drink enough water when theyre on bulk forming laxatives because…

A

avoids intestinal obstruction

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12
Q

name 5 stimulant laxatives

A
  • bisacodyl
  • sodium picosulfate
  • senna
  • co-danthramer
  • co-danthrusate
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13
Q

co-danthramer and co-danthrusate are what kind of laxatives?

A

stimulant

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14
Q

how to stimulant laxatives work and what is a common SE

A

increase intestinal motility, peristalsis
often cause abdominal cramps

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15
Q

avoid stimulant laxatives if …

A

intestinal obstruction

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16
Q

use of co-danthamer and co-danthrusate

A

only used in palliative care/terminally ill because of the potential carcinogenecity and genotoxicity

17
Q

this laxative is believed to act as a stimulant and faecal softener

18
Q

glycerol suppositories act as ..

A

lubricant and rectal stimulant due to its mild irritant action

19
Q

how do faecal softeners work

A

decreasing surface tension and increasing penetration of intestinal fluid into faecal mass

20
Q

these two laxatives have faecal softening properties

A

docusate (stimulant and softener)
glycerol (lubricant and rectal stimulant)

21
Q

what laxative class would enemas containing arachnis oil fall into and why?

A

faecal softeners
they lubricate and soften impacted faeces to promote bowel movement

22
Q

Liquid paraffin has been used as a lubricant. However, use with caution because of adverse effects e.g.

A

anal seepage
risk of granulomatous disease of GIY
lipid pnuemonia on aspiration

23
Q

how do osmotic laxatives work

A

increase amount of water in large bowel by draining fluid from body into bowel or retaining the fluid they were adminsitered with

24
Q

explain why lactulose is useful in hepatic encephalopathy

A
  • not absorbed from the GIT
  • produces osmotic diarrhoea of low faecal pH and discourages proliferation of ammonia producing organisms
25
name 2 osmotic laxatives
macrogol lactulose
26
ensure macrogol is taken with sufficient fluid to ..
reduce dehydration
27
name two other drugs that are used in constipation
linaclotide prucalopride
28
MOA lincalotide and when is it used
guanylate cyclase-C receptor agonist licensed for treatment of moderate to severe IBS associated with constipation increases intestinal fluid secretion and transit decreases visceral pain
29
prucalopride MOA and use
selective 5HT3 receptor agonist has pro kinetic properties (promotes movement in GIT) licensed for chronic constipation in adults when other laxatives have failed to provide adequate response
30
are bowel cleansing preparations used for constipation
no
31
when are bowel cleansing preparations used
before colonic surgery, colonoscopy or radiological examination to ensure bowel is free of solid contents