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Controller Meds Asthma/COPD Flashcards

Name generic name, drug class, age group, dosage form, and adverse effects/clinical pearls

1
Q

Prevent and control inflammation

A

Inhaled corticosteroids (ICS)

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2
Q

QVAR

A

ICS
Beclomethasone
Redihaler (MDI)
5yrs-adult

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3
Q

Adverse effects for ICS

A

oral thrush, cough, dysphonia

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4
Q

Counseling tips for ICS

A

*Rinse mouth and spit after use to prevent thrush
*Most effective long-term control therapy for asthma
*May increase the risk of pneumonia in patients with COPD
*Titrate to lowest effective dose
*Budesonide (Pulmicort Respules) should use jet nebulizer and should not be mixed with other nebulizer meds
*High doses increase the risk for systemic side effect

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5
Q

Pulmicort

A

ICS
Budesonide
Flexhaler
5 yrs-Adult

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6
Q

Pulmicort Respules

A

ICS
Budesonide
Nebulizer Solution
0yr-11yrs

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7
Q

Alvesco

A

ICS
Ciclesonide
HFA
5yrs-adult

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8
Q

Flovent
ArmonAir Digihaler

A

ICS
Fluticasone Propionate
HFA, DPI, Aerosol Powder Inhaler
0yrs-adult

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9
Q

Arnuity Ellipta

A

ICS
Fluticasone Furoate
Ellipta
5yrs-adult

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10
Q

Asmanex

A

ICS
Mometasone
HFA, Twisthaler
5yrs-adult

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11
Q

Bronchial smooth muscle relaxation and inhibit hypersensitivity mediators from mast cells (histamines, leukotrienes)

A

Long Acting Beta Agonist (LABA)
(increases cAMP)

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12
Q

LABA Adverse Effects

A

tachycardia, headache, tremor, hypokalemia

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13
Q

LABA Box warning

A

*Should not be used alone for asthma management (increased risk of asthma related death)
*Increasing hospitalizations in pediatric and adolescent patients
*Prolonged QT seen with intentional overdoses
*Not for acute symptoms
*May be helpful for exercise induce bronchospasm
*Formoterol and indacaterol capsules should not be taken orally

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14
Q

LABA Peds considerations

A

Most children <4 yo cannot provide sufficient inspiratory flow for adequate lung delivery with a DPI

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15
Q

Brovana

A

LABA
Arformoterol tartrate
Nebulizer Solution
Adult COPD only

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16
Q

Perforomist

A

LABA
Formoterol
Nebulizer solution
Adult COPD only unless combo with ICS

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17
Q

Arcapta Neohaler

A

LABA
Indacaterol
Neohaler
Adult COPD only

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18
Q

Striverdi Respimat

A

LABA
Olodaterol
Respimat
Adult COPD only

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19
Q

Serevent

A

LABA
Salmeterol
Diskus
5yrs-adult

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20
Q

Blocks the bronchoconstrictor effects of ACh on M3 and M2 receptors

A

LAMA

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21
Q

LAMA adverse effects

A

dry mouth, dizziness, blurred vision, upper RI, and paradoxical bronchospasms

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22
Q

Turdorza Pressair

A

LAMA
Aclidinium
DPI
Adult COPD only

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23
Q

Seebri Neohaler

A

LAMA
Glycopyrrolate
DPI, Nebulization soln
Adult COPD only

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24
Q

Yupelri

A

LAMA
Revefenacin
Nebulization solution
Adult COPD only

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25
Spiriva
LAMA Tiotropium HandiHaler, Respimat Handi- adult COPD Respimate- 12yrs-adult
26
Incruse Ellipta
LAMA Umeclidinium DPI Adult COPD only
27
ICS/LABA Clinical Pearls
LABA is recommended in combo with ICS. This assist with patient adherence
28
Advair
ICS/LABA Fluticasone/Salmeterol DPI, HFA MDI 5yrs- adult
29
AirDuo and AirDuo Digihaler
ICS/LABA Fluticasone/Salmeterol Respiclick (DPI) Adult
30
Symbicort
ICS/LABA Budesonide/Formoterol HFA MDI 5yrs-adult
31
Dulera
ICS/LABA Mometasone/Formoterol MDI Adult
32
Breo Ellipta
ICS/LABA Fluticasone/Vilanterol DPI Adult
33
LABA/LAMA clinical pearls
*COPD only *Not indicated for treatment of acute deteriorations
34
Stiolto Respimat
LABA/LAMA Olodaterol/Tiotropium Respimate Adult COPD only
35
Anoro Ellipta
LABA/LAMA Vilanterol/Umeclidinium Ellipta Adult COPD only
36
Utibron Neohaler
LABA/LAMA Indacaterol/Glycopyrronium Neohaler Adult COPD only
37
Bevespi Aerosphere
LABA/LAMA Formoterol/Glycopyrronium Aerosphere Adult COPD only
38
Duaklir Pressair
LABA/LAMA Formoterol/Aclidinium DPI Adult COPD only
39
Trelegy Ellipta
LABA/LAMA/ICS Fluticasone/Umeclidinium/Vilanterol Ellipta Adult- Asthma/COPD
40
Breztri Aerosphere
LABA/LAMA/ICS Budesonide/Glycopyrrolate/Formoterol Fumarate Aerosphere Adult COPD only
41
Intal
Mast cell stabilizer Cromolyn Nebulizer solution 2yrs-adult
42
Mast cell stabilizer Adverse Effects
High incidence of unpleasant taste, rare cardiac arrhythmias, coughing, dyspnea, sore throat
43
Mast cell stabilizer clinical pearls
*Less effective than low-dose ICS *Prevents increase in bronchial hyperreactivity seen in allergy season
44
Leukotriene modifiers adverse effects
Neuropsychiatric events, Churg-Strauss Syndrom, increased hepatic transaminases
45
Leukotriene modifiers clinical pearls
*Less effective than low dose ICS and ICS/LABA in asthma *Have not be adequately trialed in COPD
46
Singulair
Leukotriene Modifiers Montelukast Tablets (chewable), granule packets 1 yr-adult
47
Accolate
Leukotriene Modifiers Zafirlukast Tablets 5 yrs-adult
48
Zyflo CR
Leukotriene Modifiers Zileuton IR, ER tablets Adult
49
Bronchodilation through inhibition of PDE III and PDE IV
Methylxanthines
50
Methylxanthines adverse effects
insomnia, GI upset, hyperactivity, hypotension, tremor
51
Theochron
Methylxanthines Theophylline ER 12, 24 hr tablets ER 24 hr capsules Liquid
52
Inhibits binding to receptors on mast cells and basophils, inhibit mediator release and attenuation of early- and late-phase allergic response
Anti-IgE
53
Xolair
Anti-IgE Omalizumab Syringe with reconstitution 6yrs-adult
54
Anti-IgE adverse effects
headache, injection site reaction, arthralgias, thrombocytopenia, pharyngitis, sinusitis, upper RT infection
55
Anti-IgE clinical pearls
*Do not give more than 150mg per injection site *Monitor for anaphylaxis before and after injection *Approved for mod-severe asthma in patients w inadequately controlled use of ICS
56
Blocks binding to the alpha chain of the IL-5 receptor complex, which results in reduced production and survival of eosinophils
Anti-IL5
57
Nucala
Anti-IL5 Mepolizumab Injection 6yrs-adult
58
Cinqair
Anti-IL5 Reslizumab Solution for injection Adult
59
Fasenra
Anti-IL5 Benralizumab Auto inject or prefilled syringe adult
60
Blocks binding to reduce eosinophil trafficking and IgE reactions while also blocking IL-13 to reduce mucus secretion and airway remodeling
Anti-IL4/IL13
61
Dupixent
Anti-IL4/IL13 Dupilumab Injection Adult
62
Daliresp
Phosphodiaesterase-4 Inhibitors Roflumilast Tablets Adult- COPD only

Therapeutics (16 decks)

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