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Flashcards in COPD Deck (40)
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1

What are some of the other names for COPD?

- Chronic airflow limitation (CAL)
- Chronic obstructive lung disease (COLD)
- Chronic obstructive airway disease (COAD)
- Obstructive lung disease (OLD)

2

What is COPD?

- Progressive airflow limitation
- Not fully reversible
- Abnormal inflammatory response

3

What is the gold standard for diagnosing, assessing and monitoring COPD?

Spirometry - FEV1 is the best predictor of mortality

4

What spirometry values are indicative of COPD?

- FEV1/FVC ratio < 70%
- FEV1 < 80% predicted after bronchodilator medication

5

What are the characteristics of mild COPD?

- FEV1: 60-80% predicted
- Few symptoms, no effect with ADL
- No complications

6

What are the characteristics of moderate COPD?

- FEV1 40-59% predicted
- Increasing dyspnoea
- Increasing limitation on ADL
- Consider sleep apnoea

7

What are the characteristics of severe COPD?

- FEV1 < 40% predicted
- Dyspnoea on minimal exertion
- ADLs severely affected
- Complications include severe hypoxaemia, hypercapnia, pulmonary hypertension, heart failure

8

What conditions contribute to COPD?

- Chronic bronchitis
- Emphysema
- Asthma

9

What causes an obstructive defect?

- Partial occlusion of airway lumen
- Inflammation of airway wall/bronchial smooth muscle constriction
- Destruction of lung parenchyma (tissue surrounding conducting airways)

10

What are the characteristics of chronic bronchitis?

- Patient coughs on most days at least 3 consecutive months for at least 2 years
- Blue bloaters presentation common

11

What are the characteristics of pulmonary emphysema?

- Permanent enlargement of airspaces distal to terminal bronchioles
- Destruction of parenchyma
- Collapsed airways
- Pink puffers

12

What are some of the signs and symptoms of COPD?

- Breathlessness
- Cough/sputum production
- Wheeze
- Chest pain
- Weight loss
- Depression
- Muscular weakness
- Osteoporosis

13

What are the risk factors for COPD?

- Genes
- Tobacco smoke
- Occupational dusts
- Air pollution
- Asthma
- SES

14

How many pack years are associated with approx 80% of COPD patients?

History of at least 20 pack years
(1 pack year = 20 cigarettes per day for 1 year)

15

What are some of the evidence-based treatments for optimising function in COPD?

- Bronchodilators
- Pulmonary rehabilitation
- Prevention/treatment of osteoporosis
- Treatment of hypoxaemia & pulmonary hypertension
- Surgical approach for some patients

16

What is the normal pressure for pulmonary circulation?

25/10mmHg

17

What is hypoxic pulmonary vasoconstriction?

- Produced by smooth muscles cells in pulmonary arterioles
- Can improve V/Q matching
- Can increase the strain on the right side of the heart

18

What factors in COPD lead to increased pulmonary artery pressures and right heat failure/strain?

- Loss of vascular surface due to loss of lung parenchyma
- Compression of vascular bed due to hyperinflation
- Hyperviscosity of blood due to polycythemia
- Left ventricular failure
- Vessel changes due to inflammation
- Pulmonary embolism
- Hypoxic vasoconstriction

19

What are the indications for home O2 in COPD?

- Nocturnal O2 (SpO2 <88%)
- Role in exercise as supplement
- Arterial PaO2 < 55mmHg on room air at rest/awake
- Daytime PaO2 55-59mmHg & evidence of organ damage/heart failure

20

What are some of the evidence-based treatments for preventing deterioration in COPD?

- Smoking cessation
- Treatment of nicotine dependence
- Influenza immunisation
- Mucolytic medications
- Long term oxygen therapy

21

What are some of the exacerbations of COPD?

- Increased dyspnoea
- Increased sputum volume/purulence (pus)
- Increased cough
- Increased wheeze
- Fever
- URTI

22

What are some of the causes of COPD exacerbations?

- Respiratory infection (50%)
- Congestive cardiac failure (25%)
- Unknown causes (25%)

23

What are some of the evidence-based treatments for managing exacerbations in COPD?

- Early diagnosis/treatment
- Inhaled bronchodilators
- Systemic corticosteroids
- Antibiotics
- Controlled O2 delivery

24

Why is residual volume higher in COPD patients?

- Hyperinflation of the lungs due to loss of elastic recoil, enlarged spaces
- Unable to exhale as much air due to airways collapsing during expiration (destroyed parenchyma = floppy)
- Leaves higher residual volume (gas trapping)

25

What are the indications of hyperinflation?

- Barrel shaped chest
- Upper chest pattern of breathing
- Little lower chest expansion
- CXR: Lung fields larger/blacker, diaphragm flatter, ribs more horizontal

26

What is dynamic pulmonary hyperinflation (DPH)?

- Compensatory strategy in response to airflow limitation
- Results in increased end-expiratory lung volume above predicted RV
- Decreases airway resistance allowing increase RR
- Occurs during exercise

27

What are the disadvantages of DPH?

- Altered chest wall compliance
- Mechanical disadvantage of respiratory muscles

28

What is the effect of hyperinflation on the diaphragm?

- Length-tension relationship of fibres altered
- Decreased zone of apposition
- Medial orientation of fibres
- Decreased curvature
- Acts as fixator against abdominal contents

29

What is pulmonary rehabilitation?

- 8-12 week program of supervised exercise/education specific to COPD
- Improves dyspnoea, exercise tolerance, QOL

30

What is the impact dyspnoea in COPD?

- Lack of fitness
- Immobility
- Social isolation
- Depression