Copy of Respiratory - Sheet1 Flashcards Preview

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Flashcards in Copy of Respiratory - Sheet1 Deck (22):
1

Diphenhydramine

1) Use: Allergy, motion sickness, sleep aid
2) Class/MOA: H1 blockers 1st generation/ Reverisble inhibitors of H1 histamine receptors
3) Side effects/ADEs: sedation, antimuscarinic, anti alpha andrenergic
4) Fun Facts: Names contain "-en/-ine" or "-en/-ate"

2

Loratadine

1) Use: Allergy
2) Class/MOA: H1 blockers 2nd generation/reversible inhibitors of H1 histamine receptors
3) Side effects/ADEs: Less sedating than 1st generation because of decreased entry into CNS
4) Fun Facts: Name usually ends in "-adine"

3

Albuterol

1) Use: Asthma, acute exacerbation
2) Class/MOA: Beta 2 agonist, relaxes broncial smooth muscle

4

Salmeterol, formoterol

1) Use: Asthma, prophylaxis
2) Class/MOA: Beta 2 agonist, relaxes bronchial smooth muscle, long acting
3) Tremor, arrhythmia

5

Ipratropium, Tiotropium

1) Use: asthma, COPD
2) Class/MOA: Long Acting muscarinic antagonist/ competeitve block of muscarinic receptors, prevents bronchoconstriction

6

Beclomethasone, fluticasone

1) Use: 1st line for chronic asthma
2) Class/MOA: Corticosteroid/ inhibits the synthesis of virtually all cytokines. Inactivates NFkB (transcription factor that induces production of TNF alpha and other inflammatory agents)
4) Take a few hrs-days to kick in, used for "late relief" of an asthma attack
Remember to rinse out mouth!! don't want thrush - eww!

7

Montelukast, zafirlukast

1) Use: Block Asthma, especially aspirin induced
2) Antileukotrienes/block leukotriene receptor

8

Zileuton

1) Use: Asthma
2) Class/MOA: Antileukotrienes/5 lipoxygenase pathway inhibitor, blocks conversion of arachidonic acid to leukotrienes

9

Omalizumab

1) Use: Allergic asthma resistant to inhaled steroid and long acting beta agonists
2) Class/MOA: Monoclonal anti IgE antibody, binds mosly unbound serum IgE
4) Shown to be effective in reducing dependency on oral/inhaled steroids

10

Guaifenesin

1) Use: Expectorant
2) Class/MOA: Thins respiratory secretions, doesn't suppress cough reflex

11

N-acetylcysteine

1) Use: Expectorant, CF patients, antidote for acetaminophen overdose
2) Class/MOA: Mucolytic, loosen mucous plugs (CF patients)
4) also antidote for acetaminophen OD

12

Bosentan

1) Use: Pulmonary arterial hypertension
2) Compeitively antagonizes endothelin 1 receptors, decreasing pulmonary vascular resistance
4) Endothelin = vasoconstrictor, stimulant of endothelial proliferation

13

Dextromethorphan

1) Use: antitussive=cough suppressant
2) Class/MOA: Antagonizes NMDA glutamate recptors.
3) Side effects/ADEs: Mild opioid effect when used in excess, mild abuse potential
4) Fun Facts: Is a synthetic codeine analog. Naloxone can be given for overdose.

14

Pseudoephedrine, phenylephrine

1) Use: Nonprescription nasal decongestants: Reduce hyperemia, edema and nasal congestion, obstructed eustachian tubes
2) Class/MOA: Sympathomimetic alpha agonist
3) Side effects/ADEs: Hypertension, CNS stimulation/anxiety (pseudoephedrine)

15

Methacholine

1) Use: Asthma challenge testing
2) Class/MOA: Muscarinic receptor agonist

16

What is bronchoconstriction mediated by?

1 ) Inflammatory processes 2) prasympathetic tone so therapy is direct at these 2 pathways

17

Dimenhydrinate

1) Use: Allergy, motion sickness, sleep aid
2) Class/MOA: H1 blockers 1st generation/ Reverisble inhibitors of H1 histamine receptors
3) Side effects/ADEs: sedation, antimuscarinic, anti alpha andrenergic
4) Fun Facts: Names contain "-en/-ine" or "-en/-ate"

18

Chlorpheniramine

1) Use: Allergy, motion sickness, sleep aid
2) Class/MOA: H1 blockers 1st generation/ Reverisble inhibitors of H1 histamine receptors
3) Side effects/ADEs: sedation, antimuscarinic, anti alpha andrenergic
4) Fun Facts: Names contain "-en/-ine" or "-en/-ate"

19

Fexofenadine

1) Use: Allergy
2) Class/MOA: H1 blockers 2nd generation/reversible inhibitors of H1 histamine receptors
3) Side effects/ADEs: Less sedating than 1st generation because of decreased entry into CNS
4) Fun Facts: Name usually ends in "-adine"

20

Desloratadine

1) Use: Allergy
2) Class/MOA: H1 blockers 2nd generation/reversible inhibitors of H1 histamine receptors
3) Side effects/ADEs: Less sedating than 1st generation because of decreased entry into CNS
4) Fun Facts: Name usually ends in "-adine"

21

Cetirizine

1) Use: Allergy
2) Class/MOA: H1 blockers 2nd generation/reversible inhibitors of H1 histamine receptors
3) Side effects/ADEs: Less sedating than 1st generation because of decreased entry into CNS
4) Fun Facts: Name usually ends in "-adine"

22

Theophylline

1) asthma
2) Methylxanthine; inhibits phosphodiesterase --> incr cAMP --> bronchodilation
3) Narrow therapeutic index: Cardiotox/arrhythmias, neurotox/seizures, abdml pain/vomiting
4) metabolized by P450. Blocks actions of adenosine