Copy of Toxicities and Side Effects - Sheet1 Flashcards Preview

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Flashcards in Copy of Toxicities and Side Effects - Sheet1 Deck (73)
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1

Tox: Acetaminophen

Rx: N-acetylcysteine (replenishes glutathione)

2

Tox: Salicylates

Rx: NaHCO3 (alkalinize urine), dialysis

3

Tox: Amphetamines (basic)

Rx: NH4Cl (acidify urine)

4

Tox: AchE inhibitors, organophosphates

Rx: Atropine, Pralidoxime

5

Tox: Antimuscarinic, anticholinergic agents

Rx: Physostigmine salicylate, control hyperthermia

6

Tox: B-blockers
-Bradycardia, Hypotension, CV collapse

Rx: Glucagon (incr cAMP in cardiac myocytes)

7

Tox: Digitalis

Rx: Normalize K+, Lidocaine, Anti-dig Fab fragments, Mg2+

8

Tox: Iron

Rx: Deferoxamine, deferasirox

9

Tox: Lead

Rx: CaEDTA, dimercaprol, succimer, penicillamine

10

tox: Mercury, arsenic, gold

Rx: Dimercaprol (BAL), succimer

11

Tox: Copper, arsenic, gold

Rx: Penicillamine

12

Tox: Cyanide

Rx: Nitrite + thiosulfate, hydroxocobalamin

13

Tox: Methemoglobin

Rx: Methylene blue, vit C

14

Tox: CO

Rx: 100% O2, Hyperbaric O2

15

Tox: Methanol, ethylene glycol (antifreeze)

Rx: Fomepizole> ethanol, dialysis

16

Tox: Opiods
-Severe sedation, respiratory depression, miosis

Rx: Naloxone/naltrexone
mu antagonists

17

Tox: Benzodiazepines

Rx: Flumazenil

18

Tox: TCAs

Rx: NaHCO3 (plasma alkalinization)

19

Tox: Heparin

Rx: Protamine

20

Tox: Warfarin

Rx: Vit K, FFP

21

Tox: tPA, Streptokinase, Urokinase

Rx: Aminocaproic acid

22

Tox: Theophylline

Rx: B-blocker for the induced cardiac arrhythmia
-give Benzodiazepine and barbiturates for induced Seizures.

23

Rxn: Coronary vasospasm

Rx: Cocaine, sumatriptan, ergot alkaloids

24

Rxn: Cutaneous flushing

Rx: Vancomycin, Adenosine, Niacine, Ca2+ channel blockers, Caspofungin (by histamine release)

VANCC

25

Rxn: Dilated cardiomyopathy

Rx: Doxorubicin (Adriamycin), daunorubicin

26

Rxn: Torsades de pointes

Rx: Class III (Sotalol) and class IA (quinidine) anti-arrhyth
*not Amiodarone

27

Rxn: Agranulocytosis

Rx: Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone

Agranulocytosis Could Certainly Cause Pretty Major Damage

28

Rxn: Aplastic anemia

Rx: Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

29

Rxn: Direct Coombs + hemolytic anemia

Rx: Methyldopa, PCN

30

Rxn: Gray baby syndrome

Rx: Chloramphenicol

31

Rxn: Hemolysis in G6PD-defic pts

Rx: Isoniazid (INH), Sulfonamides, Primaquine, ASA, Ibuprof, Nitrofurantoin, Dapsone

Hemolysis IS PAINeD

32

Rxn: Megaloblastic anemias

Rx: Phenytoin, Methotrexate, Sulfa drgs

Have a blast w PMS

33

Rxn: Thrombotic complications

Rx: OCPs (estrogens)

34

Rxn: Cough

Rx: ACE-i

35

Rxn: Pulm fibrosis

Rx: Bleomycin, Amiodarone, Busulfan

It's hard to BLAB when you have pulm fibrosis

36

Rxn: Acute cholestatic hepatitis, jaundice

Rx: Erythromycin

37

Rxn: Focal-massive hepatic necrosis

Rx: Halothane, Amanita phalloides, Valproic acid, Acetaminophen

38

Rxn: Hepatitis

Rx: INH

39

Rxn: Pseudomembranous colitis

Rx: Clindamycin, ampicillin

40

Rxn: Adrenocortical insuffic

Rx: Glucocorticoid w/drawal (HPA suppression)

41

Rxn: Gynecomastia

Rx: Spironolactone, Digitalis, Cimeditine, chronic alcohol use, estrogens, Ketoconazole

Some Drugs Create Awkward Knockers

42

Rxn: Hot flashes

Rx: Tamoxifen, Clomiphene

43

Rxn: Hyperglycemia

Rx: Niacin, tacrolimus, protease-i, HCTZ, corticosteroids, cyclosporine

44

Rxn: Hypothyroidism

Rx: Lithium, Amiodarone, Sulfonamides

Your LASt T

45

Rxn: Fat redistribution

Rx: Glucocorticoids, protease-i

46

Rxn: Gingival hyperplasia

Rx: Phenytoin, Verapamil, Cyclosporine

47

Rxn: Gout

Rx: Furosemide, Thiazides, NIacin, Cyclosporine

48

Rxn: Myopathies

Rx: Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon-a, Penicillamine, Statins, Glucocorticoids. Plus Daptomycin**

FishedD N CHIPS Give you myopathies

49

Rxn: Osteoporosis

Rx: Corticosteroids, heparin, chronic use of Omeprazole

50

Rxn: Photosensitivity

Rx: Sulfonamides, Amiodarone, Tetracycline

SAT for a photo

51

Rxn: Rash (SJS)

Rx: PCN, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital

Bad rash after a PEC SLAPP

52

Rxn: SLE-like syndrome

Rx: Hydralazine, INH, Procainamide, Phenytoin
-these drugs are acetylated in the liver! it's been found that many ppl w Lupus are Slow Acetylators.

Not HIPP to have lupus

53

Rxn: Teeth changes (kds)

Rx: Tetracyclines

54

Rxn: Tendonitis, tendon rupture, cartilage dmge

Rx: Fluoroquinolones

55

Rxn: Nephrogenic DI

Rx: Lithium, demeclocycline

56

Rxn: Fanconi's

Rx: Expired tetraycline

57

Rxn: Hemorrhagic cystitis

Rx: Cyclophosphamide, Ifosfamide (prevent by coadministering with mesna)

58

Rxn: Interstitial nephritis

Rx: Methicillin, NSAIDs, furosemide

59

Rxn: SIADH

Rx: Carbamazepine, cyclophosphamide

60

Rxn: Cichoism

Rx: Quinidine, Quinine

61

Rxn: Parkinson-like syndrome

Rx: Antipsychotics, Reserpine (inhibits dopamine --> NE), Metoclopramide

62

Rxn: Seizures

Rx: Isoniazid (if given without pyridoxine), Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide

With seizures, I BITE My tongue

63

Rxn: Tardive dyskinesia

Rx: Antipsychotics

64

Rxn: Antimuscarinic

Rx: Atropine, TCAs, H1-blockers, Antipsychotics (low potency -Thi Chlor)

65

Rxn: Disulfiram-like rxn

Rx: Metronidazole, certain Cephalosporins, Procarbazine, 1st-gen Sulfonylureas

66

Rxn: Nephrotoxicity/Ototoxicity

Rx: Aminoglycosides, Vancomycin, Loop diuretics, Cisplatin

67

Rxn: Serotonin Syndrome

Rx: Cryoheptadine (5-HT1/2 receptor antagonist, Antihistamine)

68

P-450 Inducers

Modafinil
Barbiturates
St. John's wort
Phenytoin
Rifampin
Griseofulvin
Carbamazepine
Chronic alcohol use

69

P-450 Inhibitors

Macrolides
Amiodarone
Grapefruit juice
Isoniazid
Cimetidine
Ritonavir
Acute alcohol abuse
Ciprofloxacin
Ketoconazole
Sulfonamides
Gemfibrozil
Quinidine

70

Sulfa drugs

Probenicid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide Ab's, Sulfasalazine, Sulfonylureas
-Rxns: fever, UTI, pruritic rash, SJS, hemolytic anemia, thrombocytopenia, agranulocytosis, and urticaria (hives)

71

Tox: Adenosine

-Antidote: Theophylline and caffeine

72

Tox: Serotonin (Serotonin Syndrome)
--> clonus/hyperreflexia, CV collapse (tachy), flushing, hyperthermia, diarrhea, seizures, confusion, agitation

-antidote: Cyrohepatidine (5HT1/2 antagonist)

73

1st dose hypotension

-ACE-is (make sure pt not on a diuretic --> hypovolemia --> exacerbates the medications' effects)
-A1 antagonists (e.g. Prazosin, Tamsulosin)