Flashcards in Copy of Toxicities and Side Effects - Sheet1 Deck (73)
Loading flashcards...
1
Tox: Acetaminophen
Rx: N-acetylcysteine (replenishes glutathione)
2
Tox: Salicylates
Rx: NaHCO3 (alkalinize urine), dialysis
3
Tox: Amphetamines (basic)
Rx: NH4Cl (acidify urine)
4
Tox: AchE inhibitors, organophosphates
Rx: Atropine, Pralidoxime
5
Tox: Antimuscarinic, anticholinergic agents
Rx: Physostigmine salicylate, control hyperthermia
6
Tox: B-blockers
-Bradycardia, Hypotension, CV collapse
Rx: Glucagon (incr cAMP in cardiac myocytes)
7
Tox: Digitalis
Rx: Normalize K+, Lidocaine, Anti-dig Fab fragments, Mg2+
8
Tox: Iron
Rx: Deferoxamine, deferasirox
9
Tox: Lead
Rx: CaEDTA, dimercaprol, succimer, penicillamine
10
tox: Mercury, arsenic, gold
Rx: Dimercaprol (BAL), succimer
11
Tox: Copper, arsenic, gold
Rx: Penicillamine
12
Tox: Cyanide
Rx: Nitrite + thiosulfate, hydroxocobalamin
13
Tox: Methemoglobin
Rx: Methylene blue, vit C
14
Tox: CO
Rx: 100% O2, Hyperbaric O2
15
Tox: Methanol, ethylene glycol (antifreeze)
Rx: Fomepizole> ethanol, dialysis
16
Tox: Opiods
-Severe sedation, respiratory depression, miosis
Rx: Naloxone/naltrexone
mu antagonists
17
Tox: Benzodiazepines
Rx: Flumazenil
18
Tox: TCAs
Rx: NaHCO3 (plasma alkalinization)
19
Tox: Heparin
Rx: Protamine
20
Tox: Warfarin
Rx: Vit K, FFP
21
Tox: tPA, Streptokinase, Urokinase
Rx: Aminocaproic acid
22
Tox: Theophylline
Rx: B-blocker for the induced cardiac arrhythmia
-give Benzodiazepine and barbiturates for induced Seizures.
23
Rxn: Coronary vasospasm
Rx: Cocaine, sumatriptan, ergot alkaloids
24
Rxn: Cutaneous flushing
Rx: Vancomycin, Adenosine, Niacine, Ca2+ channel blockers, Caspofungin (by histamine release)
VANCC
25
Rxn: Dilated cardiomyopathy
Rx: Doxorubicin (Adriamycin), daunorubicin
26
Rxn: Torsades de pointes
Rx: Class III (Sotalol) and class IA (quinidine) anti-arrhyth
*not Amiodarone
27
Rxn: Agranulocytosis
Rx: Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone
Agranulocytosis Could Certainly Cause Pretty Major Damage
28
Rxn: Aplastic anemia
Rx: Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole
29
Rxn: Direct Coombs + hemolytic anemia
Rx: Methyldopa, PCN
30
Rxn: Gray baby syndrome
Rx: Chloramphenicol
31
Rxn: Hemolysis in G6PD-defic pts
Rx: Isoniazid (INH), Sulfonamides, Primaquine, ASA, Ibuprof, Nitrofurantoin, Dapsone
Hemolysis IS PAINeD
32
Rxn: Megaloblastic anemias
Rx: Phenytoin, Methotrexate, Sulfa drgs
Have a blast w PMS
33
Rxn: Thrombotic complications
Rx: OCPs (estrogens)
34
Rxn: Cough
Rx: ACE-i
35
Rxn: Pulm fibrosis
Rx: Bleomycin, Amiodarone, Busulfan
It's hard to BLAB when you have pulm fibrosis
36
Rxn: Acute cholestatic hepatitis, jaundice
Rx: Erythromycin
37
Rxn: Focal-massive hepatic necrosis
Rx: Halothane, Amanita phalloides, Valproic acid, Acetaminophen
38
Rxn: Hepatitis
Rx: INH
39
Rxn: Pseudomembranous colitis
Rx: Clindamycin, ampicillin
40
Rxn: Adrenocortical insuffic
Rx: Glucocorticoid w/drawal (HPA suppression)
41
Rxn: Gynecomastia
Rx: Spironolactone, Digitalis, Cimeditine, chronic alcohol use, estrogens, Ketoconazole
Some Drugs Create Awkward Knockers
42
Rxn: Hot flashes
Rx: Tamoxifen, Clomiphene
43
Rxn: Hyperglycemia
Rx: Niacin, tacrolimus, protease-i, HCTZ, corticosteroids, cyclosporine
44
Rxn: Hypothyroidism
Rx: Lithium, Amiodarone, Sulfonamides
Your LASt T
45
Rxn: Fat redistribution
Rx: Glucocorticoids, protease-i
46
Rxn: Gingival hyperplasia
Rx: Phenytoin, Verapamil, Cyclosporine
47
Rxn: Gout
Rx: Furosemide, Thiazides, NIacin, Cyclosporine
48
Rxn: Myopathies
Rx: Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon-a, Penicillamine, Statins, Glucocorticoids. Plus Daptomycin**
FishedD N CHIPS Give you myopathies
49
Rxn: Osteoporosis
Rx: Corticosteroids, heparin, chronic use of Omeprazole
50
Rxn: Photosensitivity
Rx: Sulfonamides, Amiodarone, Tetracycline
SAT for a photo
51
Rxn: Rash (SJS)
Rx: PCN, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital
Bad rash after a PEC SLAPP
52
Rxn: SLE-like syndrome
Rx: Hydralazine, INH, Procainamide, Phenytoin
-these drugs are acetylated in the liver! it's been found that many ppl w Lupus are Slow Acetylators.
Not HIPP to have lupus
53
Rxn: Teeth changes (kds)
Rx: Tetracyclines
54
Rxn: Tendonitis, tendon rupture, cartilage dmge
Rx: Fluoroquinolones
55
Rxn: Nephrogenic DI
Rx: Lithium, demeclocycline
56
Rxn: Fanconi's
Rx: Expired tetraycline
57
Rxn: Hemorrhagic cystitis
Rx: Cyclophosphamide, Ifosfamide (prevent by coadministering with mesna)
58
Rxn: Interstitial nephritis
Rx: Methicillin, NSAIDs, furosemide
59
Rxn: SIADH
Rx: Carbamazepine, cyclophosphamide
60
Rxn: Cichoism
Rx: Quinidine, Quinine
61
Rxn: Parkinson-like syndrome
Rx: Antipsychotics, Reserpine (inhibits dopamine --> NE), Metoclopramide
62
Rxn: Seizures
Rx: Isoniazid (if given without pyridoxine), Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide
With seizures, I BITE My tongue
63
Rxn: Tardive dyskinesia
Rx: Antipsychotics
64
Rxn: Antimuscarinic
Rx: Atropine, TCAs, H1-blockers, Antipsychotics (low potency -Thi Chlor)
65
Rxn: Disulfiram-like rxn
Rx: Metronidazole, certain Cephalosporins, Procarbazine, 1st-gen Sulfonylureas
66
Rxn: Nephrotoxicity/Ototoxicity
Rx: Aminoglycosides, Vancomycin, Loop diuretics, Cisplatin
67
Rxn: Serotonin Syndrome
Rx: Cryoheptadine (5-HT1/2 receptor antagonist, Antihistamine)
68
P-450 Inducers
Modafinil
Barbiturates
St. John's wort
Phenytoin
Rifampin
Griseofulvin
Carbamazepine
Chronic alcohol use
69
P-450 Inhibitors
Macrolides
Amiodarone
Grapefruit juice
Isoniazid
Cimetidine
Ritonavir
Acute alcohol abuse
Ciprofloxacin
Ketoconazole
Sulfonamides
Gemfibrozil
Quinidine
70
Sulfa drugs
Probenicid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide Ab's, Sulfasalazine, Sulfonylureas
-Rxns: fever, UTI, pruritic rash, SJS, hemolytic anemia, thrombocytopenia, agranulocytosis, and urticaria (hives)
71
Tox: Adenosine
-Antidote: Theophylline and caffeine
72
Tox: Serotonin (Serotonin Syndrome)
--> clonus/hyperreflexia, CV collapse (tachy), flushing, hyperthermia, diarrhea, seizures, confusion, agitation
-antidote: Cyrohepatidine (5HT1/2 antagonist)
73
