Copy of Toxicities and Side Effects - Sheet1 Flashcards Preview

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Flashcards in Copy of Toxicities and Side Effects - Sheet1 Deck (73)
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1

Tox: Acetaminophen

Rx: N-acetylcysteine (replenishes glutathione)

2

Tox: Salicylates

Rx: NaHCO3 (alkalinize urine), dialysis

3

Tox: Amphetamines (basic)

Rx: NH4Cl (acidify urine)

4

Tox: AchE inhibitors, organophosphates

Rx: Atropine, Pralidoxime

5

Tox: Antimuscarinic, anticholinergic agents

Rx: Physostigmine salicylate, control hyperthermia

6

Tox: B-blockers
-Bradycardia, Hypotension, CV collapse

Rx: Glucagon (incr cAMP in cardiac myocytes)

7

Tox: Digitalis

Rx: Normalize K+, Lidocaine, Anti-dig Fab fragments, Mg2+

8

Tox: Iron

Rx: Deferoxamine, deferasirox

9

Tox: Lead

Rx: CaEDTA, dimercaprol, succimer, penicillamine

10

tox: Mercury, arsenic, gold

Rx: Dimercaprol (BAL), succimer

11

Tox: Copper, arsenic, gold

Rx: Penicillamine

12

Tox: Cyanide

Rx: Nitrite + thiosulfate, hydroxocobalamin

13

Tox: Methemoglobin

Rx: Methylene blue, vit C

14

Tox: CO

Rx: 100% O2, Hyperbaric O2

15

Tox: Methanol, ethylene glycol (antifreeze)

Rx: Fomepizole> ethanol, dialysis

16

Tox: Opiods
-Severe sedation, respiratory depression, miosis

Rx: Naloxone/naltrexone
mu antagonists

17

Tox: Benzodiazepines

Rx: Flumazenil

18

Tox: TCAs

Rx: NaHCO3 (plasma alkalinization)

19

Tox: Heparin

Rx: Protamine

20

Tox: Warfarin

Rx: Vit K, FFP

21

Tox: tPA, Streptokinase, Urokinase

Rx: Aminocaproic acid

22

Tox: Theophylline

Rx: B-blocker for the induced cardiac arrhythmia
-give Benzodiazepine and barbiturates for induced Seizures.

23

Rxn: Coronary vasospasm

Rx: Cocaine, sumatriptan, ergot alkaloids

24

Rxn: Cutaneous flushing

Rx: Vancomycin, Adenosine, Niacine, Ca2+ channel blockers, Caspofungin (by histamine release)

VANCC

25

Rxn: Dilated cardiomyopathy

Rx: Doxorubicin (Adriamycin), daunorubicin

26

Rxn: Torsades de pointes

Rx: Class III (Sotalol) and class IA (quinidine) anti-arrhyth
*not Amiodarone

27

Rxn: Agranulocytosis

Rx: Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone

Agranulocytosis Could Certainly Cause Pretty Major Damage

28

Rxn: Aplastic anemia

Rx: Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

29

Rxn: Direct Coombs + hemolytic anemia

Rx: Methyldopa, PCN

30

Rxn: Gray baby syndrome

Rx: Chloramphenicol