Flashcards in Copy of Toxicities and Side Effects - Sheet1 Deck (73)
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1
Tox: Acetaminophen
Rx: N-acetylcysteine (replenishes glutathione)
2
Tox: Salicylates
Rx: NaHCO3 (alkalinize urine), dialysis
3
Tox: Amphetamines (basic)
Rx: NH4Cl (acidify urine)
4
Tox: AchE inhibitors, organophosphates
Rx: Atropine, Pralidoxime
5
Tox: Antimuscarinic, anticholinergic agents
Rx: Physostigmine salicylate, control hyperthermia
6
Tox: B-blockers
-Bradycardia, Hypotension, CV collapse
Rx: Glucagon (incr cAMP in cardiac myocytes)
7
Tox: Digitalis
Rx: Normalize K+, Lidocaine, Anti-dig Fab fragments, Mg2+
8
Tox: Iron
Rx: Deferoxamine, deferasirox
9
Tox: Lead
Rx: CaEDTA, dimercaprol, succimer, penicillamine
10
tox: Mercury, arsenic, gold
Rx: Dimercaprol (BAL), succimer
11
Tox: Copper, arsenic, gold
Rx: Penicillamine
12
Tox: Cyanide
Rx: Nitrite + thiosulfate, hydroxocobalamin
13
Tox: Methemoglobin
Rx: Methylene blue, vit C
14
Tox: CO
Rx: 100% O2, Hyperbaric O2
15
Tox: Methanol, ethylene glycol (antifreeze)
Rx: Fomepizole> ethanol, dialysis
16
Tox: Opiods
-Severe sedation, respiratory depression, miosis
Rx: Naloxone/naltrexone
mu antagonists
17
Tox: Benzodiazepines
Rx: Flumazenil
18
Tox: TCAs
Rx: NaHCO3 (plasma alkalinization)
19
Tox: Heparin
Rx: Protamine
20
Tox: Warfarin
Rx: Vit K, FFP
21
Tox: tPA, Streptokinase, Urokinase
Rx: Aminocaproic acid
22
Tox: Theophylline
Rx: B-blocker for the induced cardiac arrhythmia
-give Benzodiazepine and barbiturates for induced Seizures.
23
Rxn: Coronary vasospasm
Rx: Cocaine, sumatriptan, ergot alkaloids
24
Rxn: Cutaneous flushing
Rx: Vancomycin, Adenosine, Niacine, Ca2+ channel blockers, Caspofungin (by histamine release)
VANCC
25
Rxn: Dilated cardiomyopathy
Rx: Doxorubicin (Adriamycin), daunorubicin
26
Rxn: Torsades de pointes
Rx: Class III (Sotalol) and class IA (quinidine) anti-arrhyth
*not Amiodarone
27
Rxn: Agranulocytosis
Rx: Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone
Agranulocytosis Could Certainly Cause Pretty Major Damage
28
Rxn: Aplastic anemia
Rx: Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole
29
Rxn: Direct Coombs + hemolytic anemia
Rx: Methyldopa, PCN
30
