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Flashcards in Copy of Autonomic Rx - Autonomic Deck (68)
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1

Bethanchol

1) Activates Bowel and Bladder smooth m. Post-op and neurogenic ileus and urinary retention.
2) Direct Cholinomimetic.
4) Resistant to AchE.

"Bethany call me if you want to move your bowel and bladder"

2

Carbachol

1) Glaucoma, pupillary contraction, and relief of intraocular pressure.
2) Direct Cholinomimetic.
4) "Carbon copy of Ach"

3

Pilocarpine

1) Potent stim of sweat, tears, saliva. Use in Open-angle and Closed-angle Glaucoma. Contracts ciliary m of eye (open angle) and pupillary sphincter (narrow angle)
2) Direct Cholinomimetic
4) Resistant to AchE

"cry, drool, and sweat into your PILO"

4

Methacholine

1) Challenge test --> dx of asthma.
2) Direct Cholinomimetic, stim muscarinic r in airway --> bronchoconstriction

5

Neostigmine

1) Post-op and neurogenic ileus and urinary retention, myasthenia gravis, reversal of neuromuscular jxn blockade (post-op).
2) Indirect Cholinomimetic; increases Ach (anticholinesterase)
4) No CNS penetration ("Neo CNS penetration")

6

Pyridostigmine

1) Myasthenia gravis (long acting)
2) Indirect Cholinomimetic; increases endogenous Ach, increases strength. (Anticholinesterase)
4) No CNS penetration

"pyRIDostiGMine RIDs you of your MG"

7

Edrophonium

1) Diagnosis of myasthenia gravis (SHORT acting).
2) Indirect Cholinomimetic; increases endogenous Ach (Anticholinesterase)

8

Physostigmine

1) Anticholinergic toxicity
2) Indirect Cholinomimetic; increases Ach. (Anticholinesterase)
4) crosses BBB

"Physostigmine PHYxes Atropine overdose"

9

Donepezil

1) Alzheimers
2) Indirect Cholinomimetic; increases Ach (anticholinesterase)

10

ADE of all Cholinomimetics

Exacerbation of COPD, asthma, and peptic ulcers

11

Organophosphate poisoning (e.g. Parathion)
*Farmers!

Irreversibly inhib AchE. (DUMBBELSS) Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal m and CNS, Lacrimation, Sweating, and Salivation

12

Rx for Organophosphate poisoning

Atropine + Pralidoxime = regenerate active AchE

13

Atropine Use/MOA

1) Blocks Organophosphate poisoning. Used to treat bradycardia and opthalmic applications
2) Muscarinic antagonist.

14

Atropine ADE

3) Increase body temp, rapid pulse, dry mouth, dry/flushed skin, cycloplegia, constipation. Can cause acute angle-glaucoma in elderly, urinary retention in men with BPH, hyperthermia in infants

Hot as a hare
Dry as a bone
Red as a Beet
Blind as a Bat
Mad as a Hatter
Bowel and Bladder lose their tone
and the Heart runs alone

15

Homatropine

1) Produce mydriasis and cycloplegia (paralysis of ciliary m, loss of accomodation)
2) Muscarinic antagonist

16

Tropicamide

1) Produce mydriasis and cycloplegia (paralysis of ciliary m, loss of accomodation)
2) Muscarinic antagonist

17

Benztropine

1) Rx for Parkinsons**
2) Muscarinic Antagonist

"PARK my BENZ"

18

Scopolamine

1) Motion sickness.
2) Muscarinic antagonist

19

Tiotropium

1) Rx for COPD, Asthma.
2) Muscarinic antagonist

20

Ipratropium

1) Rx for COPD, Asthma.
2) Muscarinic antagonist

21

Oxybutynin

1) Reduce urgency in mild cystitis and reduce bladder spasms.
2) Muscarinic Antagonist

Put a BUUT in your FOXY Bladder

22

Glycopyrrolate

1) Parenteral: preop --> reduce airway secretions. PO: Rx for drooling, peptic ulcer
2) Muscarinic Antagonist

Sit by the PYRR and dry yourself up

23

Epinephrine

1) Anaphylaxis, glaucoma (open angle), asthma, hypotension
2) Sympathomimetics; A1, A2, B1, B2. LOW dose selective for B2**

24

NE

1) Hypotension (but low renal perfusion)
2) Sympathomimetics; A1, A2 > B1

25

Isoproterenol

1) Torsade de pointes (tachycardia decr low QT interval), bradyarrhythmias (but can worsen ischemia)
2) Sympathomimetics; B1=B2

"Iso" = 1 (only B's) "proter" sounds like german Brother (begins w B)

26

Dopamine

1) Shock (incr renal perfusion), heart failure
2) Sympathomimetic; D1 (low dose) >B (medium dose) >A (high dose), inotropic and chronotropic

dopamine relaxes renal vascular smooth m

27

Dobutamine

1) Heart failure, cardiac stress testing.
2) Sympathomimetic; B1>B2, inotropic and chronotropic)

28

Phenylephrine

1) Hypotension (vasoconstrictor), ocular procedures (mydriatic), rhinitis (decongestant)
2) Sympathomimetic; A1>A2
4) decr NE synthesis leads to "Rebound congestion"/Tachyphalaxis. (nasal mucosa is edematous, red, bleeding)

29

Albuterol

1) Acute asthma
2) Sympathomimetic; Selective B2-agonist (B2>B1)

30

Salmeterol

1) Long-term treatment of asthma or COPD control
2) Sympathomimetic; Selective B2-agonist (B2>B1)

31

Terbutaline

1) Reduce premature uterine contractions**
2) Sympathomimetic; Selective B2-agonist (B2>B1)

32

Ritodrine

1) Reduces premature uterine contractions**
2) Sympathomimetic; B2

so you deliver at the "Rite" "Drine/time"

33

Amphetamine

1) Narcolepsy, obesity, ADD
2) Indirect Sympathomimetic/general agonist, releases stored catecholamines

34

Ephedrine

1) Nasal decongestion, urinary incontinence, hypotension
2) Indirect sympathomimetic/general agonist, releases stored catecholamines

35

Cocaine

1) Causes vasoconstriction and local anesthesia
2) Indirect sympathomimetic/general agonist. Uptake inhibitor.
4) People use this to get high. Don't give B-blockers if cocaine intoxication suspected. (can lead to unopposed A1 activation and extreme HTN)

36

Clonidine

1) HTN esp w renal disease (no decr in blood flow to kidney)
2) Sympathoplegics. Centrally acting A2-agonist. Decr central sympathetic outflow

37

Alpha-methyldopa

1) HTN esp w renal disease (no decr in blood flow to kidney)
2) Sympathoplegics. Centrally acting A2-agonist. Decr central sympathetic outflow
4) Rx for HTN in pregnancy also

38

Phenoxybenzamine

1) Pheochromocytoma (b4 removing tumor - so that release of catecholamines will not be able to overcome receptor blockage)
2) IRREVERSIBLE, Nonselective alpha blocker
3) Orthostatic hypotension, reflex tachycardia

39

Phentolamine

1) Give to pts on MAO-i who eat tyramine-containing foods
2) REVERSIBLE, Nonselective alpha blocker

40

Prazosin

1) HTN, urinary retention in BPH
2) A1 blocker
3) 1st dose orthostatic hypotension, dizziness, HA

41

Terazosin

1) HTN, urinary retention in BPH
2) A1 blocker
3) 1st dose orthostatic hypotension, dizziness, HA

42

Doxazoin

1) HTN, urinary retention in BPH
2) A1 blocker
3) 1st dose orthostatic hypotension, dizziness, HA

43

Tamsuolosin

1) HTN, urinary retention in BPH
2) A1 blocker
3) 1st dose orthostatic hypotension, dizziness, HA

44

Mirtazapine

1) Atypical Antidepressant
2) A2 antagonist and 5HT2/3 blocker
3) Sedation, incr serum cholesterol, incr appetite, dry mouth

45

Acebutolol

1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma
2) Beta1-antagonist (partial Beta-agonist)
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV block, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics

46

Betaxolol

1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma
2) Beta1-antagonist
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics

47

Esmolol

1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma
2) Beta1-antagonist (short acting)
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics

ESM: Extra Short-acting Medicine

48

Atenolol

1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma
2) Beta1-antagonist
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics

49

Metoprolol

1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma
2) Beta1-antagonist
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics

50

Propanolol

1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma
2) Non-selective B-antagonist. Decr conversion of T4 --> T3*** (use in thyroid storm)
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure sleep alteration). Use with caution in diabetics

51

Timolol

1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma
2) Non-selective B-antagonist
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics

52

Pindolol

1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma
2) Non-selective B-antagonist (partial B-agonist)
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics

53

Labetalol

1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma
2) Non-selective (vasodilatory) A and B antagonist
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics

54

Carvedilol

Non-selective (vasodilatory) A and B antagonist

55

Nadolol

Non-selective B antagonist

56

Alpha 1

Gq
-Incr vasc smooth m contraction, incr pupillary dilator m contraction (mydriasis), incr intestinal and bladder sphincter m contraction

incr bp, don't poop or pee, see in the dark

57

Alph 2

Qi
-decr NE release, decr insulin release, decr lipolysis, incr platelet aggregation

58

Beta1

Qs
-Incr HR/contractility, incr renin release, incr lipolysis

B1 wants to get your bp back up (incr HR/contractility, blood volume) and break down all that fat in the way

59

Beta2

Qs
-Vasodilation, bronchodilation, incr HR/contractility, incr lipolysis, Incr Insulin release, decr uterine tone (tocolysis), ciliary m relaxation (see far distance), incr aqueous humor production (protect the lens)

60

M1

Qq
CNS, enteric nervous system

61

M2

Qi
-decr HR and contractility of atria, decr NE release

62

M3

Qq
-Incr exocrine gland secretions (lacrimal, gastric), incr gut peristalsis, incr bladder contraction, bronchoconstriction, incr pupillary sphincter muscle contraction (miosis), ciliary muscle contraction (accomodation)

wnat to be able to digest and poop and pee in a smelly (don't breathe!) and brightly lit bathroom (small pupils) and accomodate person who wants to go next

63

D1

Qs
-Relaxes renal vasc smooth m

64

D2

Qi
-Modulates transmitter release, esp in brain

65

H1

Qq
-Incr nasal and bronchial mucus production, contraction of brionchioles, pruritus, pain

(allergic rxn basically: snotty, can't breathe, itchy, in pain!)

66

H2

Qs
-Gastic acid secretion

67

V1 (Vasopressin)

Qq
-Incr vasc smooth m contraction/vasoconstriction

68

V2 (ADH)

Qs
-Incr H2O permeability and reabsorption in the collecting tubules of the kidney (V2 is found in 2 Kidneys)
=ADH