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Flashcards in Copy of Renal - Sheet1 Deck (12)
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1

Mannitol

1) Use: Shock, drug overdose
2) Class/MOA: Osmotic diuretic
3) Side effects/ADEs: Pulmonary edema, dehydration, CHF, contraindicated in anuria
4) Fun Facts:

2

Acetazolamide

1) Use: Glaucoma, urinary alkalinization, metabolic alkalosis, altitude sickness
2) Class/MOA: Carbonic anhydrase inhibitor, prevents bicarb reabsorption in PCT
3) Side effects/ADEs: hyperchloremic metabolic acidosis, neuropathy, NH3 toxicity, sulfa allergy
-You want to take SNAACs with you on your mountain expedition!
Sulfa, Nephropathy/Parasthesias, Acidosis, Ammonia tox, (hyper)chloremia

3

Furosemide

1) Use: Edema (CHF, cirrhosis, nephrotic syndrome, pulmonary edema), HTN, hypercalcemia
2) Class/MOA: Loop diuretic. Inhibits cotransport system (Na, K, 2Cl) of thick ascnding limb, preventing hypertonicity of the medulla. Stimulates PGE release for vasodilation of afferent arteriole.. Increases calcium release.
3) Side effects/ADEs: OH DANG! (Ototoxicity, hypokalameia, dehydration, allergy-sulfa, nephritis (interstitial), gout)

4

Ethacrynic acid

1) Use: Diuresis for people with sulfa allergies
2) same as Furosemide but it's NOT a sulfa drug
3) Side effects/ADEs: OH DANG! (Same as furosemide)
4) Fun Facts: Same MOA as furosemide. Can cause hyperuricemia (never use in gout)

5

Hydrochlorothiazide

1) Use: HTN, CHF, idiopathic hypercalciuria, nephrogenic DI
2) Class/MOA: Inhibits NaCl reabsorption in early DCT, limiting diluting capacity. Decrease calcium excretion.
3) Side effects/ADEs: HyperGLUC (hyperglycemia, hyperlipidemia (cholesterol, LDL), hyperuricemia, hypercalcemia). Hypokalemic matabolic alkalosis, hyponatremia
4) Sulfa drugs

6

Spironolactone

1) Use: Hyperaldosteronism, K+ depletion, CHF
2) Class/MOA: K+ sparing diuretic. Spironolactone is a competitive aldosterone receptor antagonist in cortical collecting duct.
3) Side effects/ADEs: Hyperkalemia (arrhythmias), endocrine effects (gynecomastia and other androgen effects)
4) Fun Facts: The K+ STAys (Spironolactone, triamterene, amiloride)

7

Triamterene

1) Use: Hyperaldosteronism, K+ depletion, CHF
2) Class/MOA: K+ sparing diuretic. Triamterene and amiloride block Na channel in CCT.
3) Side effects/ADEs: Hyperkalemia (arrhythmias)
4) Fun Facts: The K+ STAys (Spironolactone, triamterene, amiloride)

8

Amiloride

1) Use: Hyperaldosteronism, K+ depletion, CHF
2) Class/MOA: K+ sparing diuretic. Triamterene and amiloride block Na channel in CCT.
3) Side effects/ADEs: Hyperkalemia (arrhythmias)
4) Fun Facts: The K+ STAys (Spironolactone, triamterene, amiloride)

9

Captopril

1) Use: HTN, CHF, diabetic renal disease, prevent heart remodeling from HTN
2) Class/MOA: Inhibit ACE to reduce angiotensin II. Renin release increases
3) Captopril's a CATCHH (Cough, Angiodema, Teratogen - renal malformation, Creatinine incr decr GFR, Hyperkalemia, 1st doseHypotension).
Avoid in BL renal artery stenosis
4) Fun Facts: ATII receptor blockers (sartans) are similar to these without the cough.

10

Enalapril

1) Use: HTN, CHF, diabetic renal disease, prevent heart remodeling from HTN
2) Class/MOA: Inhibit ACE to reduce angiotensin II. Renin release increases
3) Captopril's a CATCHH (Cough, Angiodema, Teratogen - renal malformation, Creatinine incr decr GFR, Hyperkalemia, 1st dose Hypotension).
Avoid in BL renal artery stenosis
4) Fun Facts: ATII receptor blockers (sartans) are similar to these without the cough.

11

Lisinopril

1) Use: HTN, CHF, diabetic renal disease, prevent heart remodeling from HTN
2) Class/MOA: Inhibit ACE to reduce angiotensin II. Renin release increases
3) Captopril's a CATCHH (Cough, Angiodema, Teratogen - renal malformation, Creatinine incr decr GFR, Hyperkalemia, 1st dose Hypotension).
Avoid in BL renal artery stenosis
4) Fun Facts: ATII receptor blockers (sartans) are similar to these without the cough.

12

Eplerenone

1) Use: Hyperaldosteronism, K+ depletion, CHF
2) Class/MOA: K+ sparing diuretic. Spironolactone is a competitive aldosterone receptor antagonist in cortical collecting duct.
3) Side effects/ADEs: Hyperkalemia (arrhythmias)
4) Fun Facts: The K+ STAys (Spironolactone, triamterene, amiloride)