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1
Q
  1. Characteristics
A
  1. mediated - IgE
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2
Q
  1. Characteristics
A
  1. mediated - Ab-mediated cytotoxicity; Ab attack tissue
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3
Q
  1. Characteristics
A
  1. mediated - immune complex deposition
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4
Q
  1. Characteristics
A
  1. mediated - cell mediated (TH cells)
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5
Q
  1. All others
A
  1. B27
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6
Q
  1. Mechanism
A
  1. MG
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7
Q
  1. Associated
A
  1. Wegner’s granulomatosis
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8
Q
  1. Mechanism
A
  1. Goodpasture’s syndrome
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9
Q
  1. Mechanism
A
  1. Dx - MS
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10
Q

Immunlogic features to DM1

A
  1. anti-islet cell Ab
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11
Q
  1. type of hypersensitivity
A
  1. Mechanism - Rheumatoid factor (IgM Ab to own IgG)
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12
Q
  1. mechanism
A
  1. Scleroderma
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13
Q

CREST

A

C calcinosis

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14
Q
  1. anti-Jo-1
A
  1. anti-DNA, anti-Sm - lupus
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15
Q
  1. clinical example
A
  1. defect (component) - T cells
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16
Q
  1. clinical example
A
  1. defect (component) - B cells
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17
Q
  1. clinical example
A
  1. defect (component) - B cells
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18
Q
  1. clinical example
A
  1. defect (component) - phagocytes
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19
Q
  1. clinical example
A
  1. defect (component) - complement
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20
Q
  1. Characteristics
A
  1. Dx - chronic granulomatous dis
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21
Q
  1. Characteristics
A
  1. Dx - leukocyte adhesion def (LAD)
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22
Q
  1. Characteristics
A
  1. Dx - Chediak-Higashi dis
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23
Q
  1. Characteristics
A
  1. Dx - X-linked (Bruton’s) agammaglobulinemia
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24
Q
  1. Characteristics
A
  1. Dx - selective IgA deficiency
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25
Q
  1. Characteristics
A
  1. Dx - common variable immunideficiency
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26
Q
  1. Characteristics
A
  1. Dx - SCID
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27
Q
  1. Characteristics
A
  1. Dx - Herediatary atxia-telangiectasia
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28
Q
  1. Characteristics
A
  1. Dx - Wiskott- Aldrich
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29
Q
  1. Characteristics
A
  1. Dx - Chronic mucocutaneous candidiasis
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30
Q
  1. Characteristics
A
  1. Dx - DiGeorge (congenital thymic aplasia)
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31
Q
  1. DAF, HRF, or CD59
A
  1. C1qrs, C2, or C4 - immune complex dis
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32
Q
  1. complement defects asoc w/
A
  1. humoral defects (b cells) assoc w/ - common infections (otitis mdia, sinusitis)
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33
Q

In transplant,HLA match

A

HLA match - A, B, and DR

34
Q
  1. fxn
A
  1. source - TH1 cells and NK cells
35
Q
  1. fxn
A
  1. source - TH1
36
Q
  1. fxn
A
  1. source - APCs (macrophages)
37
Q
  1. fxn
A
  1. source - Macrophages
38
Q
  1. fxn
A
  1. source - TH2
39
Q
  1. fxn
A
  1. source - Th2
40
Q
  1. fxn
A
  1. source - Th2
41
Q
  1. Activate:
A
  1. Differentiate by: IL-1, 12, and IFN-gamma (from Macro)
42
Q
  1. Inhibited by:
A
  1. differentiate by: IL-4 (from mast cells and eosinophils)
43
Q

Thymus secretes what to differentiate lymphocytes into T cells?

A

thymopoietins I and II

44
Q
  1. medulla
A
  1. Cortex - express CD3 and both CD4 and 8 and aquire TCRs
45
Q

What activates effectr T cells in periphery

A

macrophages

46
Q
  1. Cytokine response
A
  1. CD28 - binds CD80/CD86 on APC
47
Q
  1. cytokine response
A
  1. CD28 binds CD80/86 o APC
48
Q

If CD28 on T cells is downregulated …

A

CTLA-4 is upregulated and T cell is inactvated

49
Q

Papain vs Pepsin

A

Papain - cleaves Ig at the hinge region

50
Q

IgM

A

pentamer (j chain)

51
Q

IgG

A

high affinity

52
Q

IgE

A

hig affinity FcE receptors on mst cells and basophils

53
Q

IgA

A

found in secretions and mucus

54
Q

IgD

A

primarily xpr on B cell surface

55
Q

Complement is synthesized by

A

hepatocytes (in the liver)

56
Q
  1. Lectin
A
  1. classic - Ab mediated
57
Q
  1. Players
A
  1. C1, 4, 2, 3, 5-9 and Ab on surface of microbe
58
Q
  1. players
A

Mannan-binding lectin binds bacterial carbs and activates C4, 2, 3, 5-9

59
Q
  1. 6 steps
A
  1. activated by: LPS, IgA aggregates, and Cobra venom
60
Q
  1. C5a
A
  1. C3a - inflammation
61
Q

What are C3a, C4a, and C5a?

A

Anaphylatoxins - recrut phagocytes, promote inflammation, chemokines, and vasodilation

62
Q
  1. mechanism
A
  1. evasion tactic - resistance to phagocytosis
63
Q
  1. mechanism
A
  1. evasion tactic - resistance to phagocytosis
64
Q
  1. mechanism
A
  1. evasion tactic - resistance ROS
65
Q
  1. mechanism
A
  1. evasion tactic - resistance to complement
66
Q
  1. mechanism
A
  1. evasion tactic - resistance to complement
67
Q
  1. fxn
A
  1. liver in response to IL-6
68
Q
  1. associated with
A
  1. IFN-a - leukocytes
69
Q
  1. associated with
A
  1. IFN-g made by NK, CD4 Th1 and CD8 T cells
70
Q
  1. Decrease
A
  1. ribonucleases, prteases, (prevent replication); MHC I xpr (promote recog) and cytotoxic actions of NK cells
71
Q
  1. increase
A
  1. phagocytic andmicrobial capabilities of macroph.
72
Q
  1. Decrease
A

Cell walls of bacteria that contain endotowin (LPS)

73
Q

Acute phase proteins

A

IL-1, IL-6 and TNF

74
Q

IFN a and b have what kind of activity

A

antiviral

75
Q

IL-5 activates

A

eosinophils

76
Q

2 myeloid series need _

A
  1. IL-7
77
Q

Monocytes/macrophages are identified by what marker

A

CD14

78
Q

NK cells activated by

A

IL-1, IL-2, IL-18 (esp!) and IFN-g

79
Q

Innate immunity can recognize broad classes of microbial pathogens based on pathogen associated molecular patterns (PAMPs) - 4 examples

A

LPS/endotoxin

80
Q

TLR 9

A

TLR 1 - triacyl lipoproteins

81
Q
  1. pathway for each
A
  1. superoxide, hypochlorite, hydroxyl radical

Micro (28 decks)

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