CTL week 10 Flashcards
describe the 6 main routes of administration of drugs?
hint: “or pies”
describe the main routes of administration of drugs?
Answer:
Oral
Rectal (up anus)
Parenteral (Intravenous, Subcutaneous, intramuscular, Intrathecal)
Inhalation
Epithelial (lipid soluble drug)
Subligual (under the tongue, b/c quickly absorbed in blood)
advantages and disadvantages of Rectal administration of Drug are?
advantages and disadvantages of Rectal administration of Drug are?
Answer: local effect on the GI tract
(Exp: anti-inflammatory drug)
advantages and disadvantages of sublingual administration of Drug are?
advantages and disadvantages of sublingual administration of Drug are?
Answer:
- Rapid absorption into systemic circulation.
- No passage through liver
advantages and disadvantages of Epithelial administration of Drug are?
advantages and disadvantages of Epithelial administration of Drug are?
Answer:
applied on the skin
lipid soluble drug
(Exp: oestrogen patches)
advantages and disadvantages of inhalation administration of Drug are?
advantages and disadvantages of inhalation administration of Drug are?
Answer: site of action is the lung.
advantages and disadvantages of subcutaneous administration of Drug are?
advantages and disadvantages of subcutaneous administration of Drug are?
Answer:
- slower rates of absorption
- longer duration
advantages and disadvantages of Intravenous administration of Drug are?
advantages and disadvantages of Intravenous administration of Drug are?
Answer:
- immediate effect
- drugs which are broken down by first pass metabolism can be given
- disadvantage, infection, overdose
A drug will be ionized when exposed to a pH ______ its pKa.
A drug will be ionized when exposed to a pH ___opposite___ its pKa.
an ionized drug is _____ soluble.
an ionized drug is ___water___ soluble
does the permeability of capillaries determine the rate at which drugs enter compartments?
does the permeability of capillaries determine the rate at which drugs enter compartments?
Answer: yes
how do you calculate the volume of distribution (VD)?
is this a real number or relative number?
what is the volume of distribution (Vd)?
Answer: total amount of drug in body / plasma drug conc
is this a real number or relative number?
Answer: this is a relative number
what is the purpose of the VD?
what is the purpose of the VD?
Answer:
- to determine the half-life of drugs
- to determine required dosage (how much will cell take)
what are the 2 ways of eliminating drugs from the body?
what are the 2 ways of eliminating drugs from the body?
Answer:
- metabolism
- excretion
