MTC Week 6 Flashcards
pyruvate kinase is activated and inhibited by what allosteric effectors and what covalent modification?
pyruvate kinase is activated and inhibited by what?
Allosteric activation by F1,6BP
Allosteric inhibition by Acetyl Coa & ATP
Covalent modificatioin
insulin = dephosphorylation (active) of pyruvate kinase
Glucagon = phosphorylation (inactive) of pyruvate kinase
phosphofructokinase-1 (PFK) is activated and inhibited by what kind of allosteric regulation?
phosphofructokinase-1 (PFK) is activated and inhibited by what?
allosteric Activator: AMP, ADP, F2,6BP
allosteric inhibitor: ATP, citrate
what makes F-2,6-BP?
what makes F-2,6-BP?
Answer: phosphofructokinase-2 (PFK-2)
How does insulin and glucagon regulate F2,6BP ?
How does insulin and glucagon regulate F2,6BP ?
Answer: insulin (high glucose) -> increase of F2,6BP
glucagon (low glucose) -> decrease of F2,6BP
UDP-glucose is synthesized from ?
UDP-glucose is synthesized from ?
Answer; UDP-G is made from Glucose-1 Phosphate which is made from Glucose-6 phosphate.
insulin adds a phosphate to which enzyme to promote glycogen production?
insulin adds a phosphate to which enzyme to promote glycogen production?
Answer: phosphate added to glycogen synthase
glucagon adds a phosphate to which enzyme to promote glycogen break down?
glucagon adds a phosphate to which enzyme to promote glycogen break down?
Answer: phosphate added to Glycogen phosphorylase
muscle cells do not have _________ which liver cells have because muscle cells do not release glucose into the blood.
muscle cells do not have [Glucose-6-phosphatase] which liver cells have because muscle cells do not release glucose into the blood.
in prokaryotes where does glycolysis and fermentation happen?
in prokaryotes where does glycolysis and fermentation happen?
Answer: cytoplasm
in prokaryotes where does citric acid cycle occur?
in prokaryotes where does citric acid cycle occur?
Answer: cytoplasm
where does pyruvate oxidation and respiratory chain happen in prokaryotes?
where does pyruvate oxidation and respiratory chain happen in prokaryotes?
Answer: plasma membrane
