Cutaneous Drug Eruptions

Question 1

when does a cutaneous drug eruption usually resolve?

Answer 1

when the drug is withdrawn

Question 2

which age group is most likely to suffer a cutaneous drug eruption?

Answer 2

young adults

females

Question 3

what underlying conditions can predispose to cutaneous drug eruptions?

Answer 3

viral infections

cystic fibrosis

Question 4

what is the most common type of drug eruption?

Answer 4

exanthematous

Question 5

what type of reaction is an exanthematous drug eruption?

Answer 5

delayed hypersensitivity (IV)

Question 6

describe the appearance of an exanthematous eruption

Answer 6

widespread symmetrical rash

mucous membranes spared

Question 7

what are common associated symptoms of an exanthematous eruption?

Answer 7

itch

fever

Question 8

when does an exanthematous eruption occur?

Answer 8

4-21 days after first taking the drug

Question 9

name four drugs associated with exanthematous eruptions

Answer 9

penicillin
erythromycin
allopurinol
NSAIDs

Question 10

what are the two possible processes behind an urticarial drug reaction?

Answer 10

immediate IgE mediated reaction on rechallenge

direct release of mast cell components on first exposure

Question 11

name four drugs that can cause urticarial drug reactions

Answer 11

beta lactam antibiotics
aspirin
opiates
NSAIDs

Question 12

what are two types of bullous drug eruptions?

Answer 12

acneiform

AGEP

Question 13

what does AGEP stand for?

Answer 13

acute generalised exanthematous pustulosis

Question 14

name three drugs that can cause an acneiform bullous drug eruption

Answer 14

glucocorticoids
androgens
lithium

Question 15

name three drugs that can cause AGEP

Answer 15

antibiotics
CCB
anti malarials

Question 16

what three drugs can cause drug induced bullous pemphigoid?

Answer 16

ACEi
penicillin
furosemide

Question 17

what drug can trigger linear IgA disease?

Answer 17

vancomycin

Question 18

describe the appearance of a fixed drug eruption

Answer 18

well demarcated plaques

red and painful

Question 19

what body sites are often affected by fixed drug eruptions?

Answer 19

hands
genitalia
lips
occasionally the oral mucosa

Question 20

when a fixed drug eruption resolves, what can be seen?

Answer 20

persistent pigmentation

may re-occur

Question 21

name four drugs associated with fixed drug eruptions

Answer 21

tetracycline
paracetamol
NSAIDs
carbamazepine