Pathology Flashcards
(50 cards)
name a benign epidermal tumor
seborrheic keratosis
who commonly gets seborrheic keratosis?
older individuals
what is seborrheic keratosis?
a benign proliferation of epidermal keratinocytes
where do seborrheic keratosis’ normally affect?
face
trunk
what is lesser trelat sign and what can it indicate?
eruptive appearance of many seborrheic keratosis lesions
may indicate internal malignancy
name two precursors for SCC
bowen’s disease
actinic keratosis
where is bowen’s disease commonly found?
the legs
what is bowen’s disease?
squamous cell carcinoma in situ
describe the appearance of bowen’s disease
scaly patch with an irregular border
where is actinic keratosis often found?
the head and neck
what is actinic keratosis?
variable epidermal dysplasia
what virus is SCC associated with?
HPV 16
what are the two non melanocytic skin malignancies?
basal cell carcinoma
squamous cell carcinoma
where is basal cell carcinoma found?
sun exposed sites
who is most commonly affected by BCC?
middle aged and elderly
what are the three main subtypes of BCC?
nodular
superficial
infiltrative
what is another name for infiltrative BCC?
morphoeic
where are melanocytes derived from?
the neural crest
what gene turns phaeomelai into eumelanin?
MC1R
what does one defective copy of MC1R cause?
freckles
what does two defective copies of MC1R cause?
red hair
freckles
what are ephilides?
freckles
patchy increase in melanin pigmentation
when do freckles develop?
after UV exposure
what is another name for actinic lentigines?
solar lentigines
age/liver spots
