Flashcards in Cutaneous Immunology Deck (39):
What are the inflammatory mediators of innate immunity response?
mast cells and eosinophils
What are the phagocytic cells of the innate immunity response?
neutrophils and macrophages
how long does initial stimulation of the adaptive immune response take?
what cytokines do TH1 cells release?
IFN-y and TNF
What do IFN-y and TNF do?
activate macrophages, dendritic cells, neutrophils and cytotoxic T cells
What do TH1 cells direct their attack against?
viruses, tumors, and intracellular pathogens
Which cells are responsible for delayed (Type IV) hypersensitivity?
What do Th2 cells release?
IL-4, IL-5 and IL-10
What do IL-4, IL-5 and IL-10 do?
activate eospinophils and plasma cells and lead to IgE production
What do Th2 cells attack against?
parasites and extracellular microbes
What cells stimulate humoral immunity?
Which cells are implicated in the development of autoimmune diseases?
Th1 cells are linked to what 3 pathologies?
Allergic contact dermatitis
What 3 pathologies are Th2 cells linked to?
What are 5 common allergens?
What is patch testing used for?
To detect common allergens that could be causing allergic contact dermatitis
What are haptens?
molecules that are too small to be recognized independently but are capable of stimulating the immune system after binding native proteins
Where does atopic dermatitis affect infants?
face, scalp and extensor aspects of the extremities
Where does atopic dermatitis affect older children and adults?
flexural regions and face
colonization of what bacteria can contribute to atopic dermatitis?
what is the genetic defect associated with atopic dermatitis?
What is a good treatment for prevention of atopic dermatitis flares?
bleach baths--> kills colonization of staph areus
What viral infection are those with atopic dermatitis at risk of contraction?
eczema herpeticum (due to impaired cell-mediated immunity
What syndrome is associated with destructive arthritis?
What is keobnerization?
trauma to the skin that leads to more inflammation (scratching)
What is guttate psoriasis?
presents with small round papules and plaques; often precipitated by strep infection
What is the defining histological characteristic of psoriasis?
presence of neutrophils
What disease presents with angioedema?
What is angioedema?
affects the deep dermis and causes painful swelling often of the lips and face
What is the most defining feature of urticaria?
evanesence--> symptoms resolve after 24 hours
Urticaria is a ____ type hypersensitivity
What is dermatographism?
when light scratching results in itchy linear wheals that can be "read" minutes later
What causes Dermatographism?
very excitable mast cells
What medications most commonly cause drug eruptions?
antibiotics, anticonvulsants and NSAIDS
what is the systemic parallel of allergic contact dermatitis?
Exanthematous drug eruption
What is DRESS?
DRug Eruption with Eosinophilia and Systemic Symptoms; characterized by exanthematous eruption with fever, lymphadenopathy, and facial edema
When is the onset of DRESS
15-40 days after initial stimuli
When does ACE-inhibitor angioedema occur?
days to YEARS after exposure