CV Drugs 3 Flashcards Preview

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Flashcards in CV Drugs 3 Deck (28):
1

name two ace inhibitors

enalapril and benazepril

2

where are local RAS systems located?

heart, kidney, brain, adrenal glands, etc.

3

what organ converts enalapril and benazepril?

liver

4

T/F: benazepril has more hepatic clearance than renal clearance compared to enalapril

TRUE, enalapril is only renal clearance

5

which ace inhibitor would be more appropriate for a patient with impaired renal function?

benazepril

6

between benazepril and enalapril which drug is longer acting?

benazepril

7

what are ace inhibitors used to treat?

-CHF
-hypertension
-protein losing renal disease (reduce intraglomerular hypertension)

8

T/F: benazepril has more GI signs than enalapril

FALSE, opposite

9

what group of drugs pose a risk of worsening azotemia due to decreasing GFR?

ace inhibitors, watch out w/ patients w/ systemic hypertension & pre-exisiting renal disease

10

T/F: sildenafil is a phosphodiesterase inhibitor

TRUE, PDE V inhibitor > increased cGMP > NO mediated vasodilation

11

what muscle does sildenifil work on?

smooth muscle of pulmonary vasculature

12

what is sildenifil primarily used to treat for?

pulmonary hypertension

13

what drug is used to treat eisenmenger's syndrome?

sildenafil

14

T/F: below are all categories of pulmonary hypertension
-pulmonary thromboembolism
-chronic respiratory disease
-cardiac disease
-heartworm disease
-neoplasia or obstructive disease

TRUE, all might indicate the use of sildenafil

15

what do you want to avoid using concurrently w/ sildenafil?

nitrates

16

name three direct-acting vasodilators

nitroprusside, nitroglycerine, hydralazine

17

what potent endogenous vasodilator do nitrates increase the formation of?

nitric oxide (NO) > activates guanylyl cyclase

18

what is the result of the MOA of nitrates?

direct arteriolar and venous vasodilation

19

what is the MOA of hydralazine?

increases local PGI2 concentration altering cellular calcium metabolism in smooth muscle

20

T/F: like nitrates, hydralazine results in direct arteriolar and venous vasodilation

FALSE, arteriolar only

21

you have a patient in a hypertensive crisis! what group of drugs do you grab?

direct-acting vasodilators (nitrates, hydralizine)

22

what direct-acting vasodilator is contraindicated with renal disease?

hydralazine, pre-treat w/ ACE-I & spironolactone to reduce risk

23

T/F: amolodipine as a ca channel blocker has clinically significant antiarrhythmic effects

FALSE

24

what is the MOA of amlodipine?

inhibits the influx of extracellular calcium across myocardial and smooth m. cell membranes > DILATION of coronary and systemic arteries

25

what are the clinical effects of amlodipine?

-negative inotropic effects
-negative chronotropic effects
-increase oxygen delivery to myocardial tissue
-decrease afterload
-coronary vasodilation
-decrease peripheral resistance
-decrease systemic BP

26

what is the drug of choice in first line treatment of hypertension in cats?

amlodipine

27

sassy the cat comes in with hypertension due to hyperthyroidism. what drug might you use?

beta-blocker is preferred (propanolol)

28

what are two things you should look out for when deciding whether to treat a patient with amlodipine?

AV block and elevated liver enzymes