Flashcards in Gastrointestinal Deck (32):
what must you always do when treating an animal for anorexia/hyporexia?
identify and treat the underlying cause!! almost always a secondary issue
what part of the brain is the appetite center and satiety center?
name two GABA agonists used to stimulate appetite
benzodiazepines (diazepam, midazolam) and propofol
T/F: propofol is more short term than benzodiazepines when used for appetite stimulation
TRUE, about 15 min. benzodiazepines are also useful short term
what can giving a cat PO diazepam cause?
why might you be cautious in giving a cat propofol to stimulate appetite?
heinz body anemia is possible if given for more than 5 days
what appetite stimulant is fairly new and only labeled for dogs?
what is the MOA of capromorelin?
ghrelin agonist, as ghrelin increases in [ ] the hypothalamus is stimulated to increase appetite
what two appetite stimulant's common side effect is sedation?
benzodiazepines and cyproheptadine
T/F: cyproheptadine is more effective in dogs than cats and takes 2-3 days to see a response
FALSE, it's more effective in cats
what is the MOA of cyproheptadine?
blocks serotonin (5-HT2) receptors, inhibits satiety center
what is the MOA of mirtazapine?
antidepressant that blocks both 5-HT2 and 5-HT3 (serotonin) receptors, increases NE centrally
T/F: mirtazapine is used more in dogs while cyproheptadine is more effective in cats
besides being an antidepressant and appetite stimulant, mirtazapine also has what effect?
T/F: cats have MORE a-2 and 5 HT receptors and FEWER D2 and H1 receptors than dogs
quick! bear just ate a whole bag of m&ms and we're 5 hours away from the nearest clinic. what can you give him to induce vomiting?
hydrogen peroxide 3%
what is the MOA of hydrogen peroxide 3% to induce vomiting?
direct irritation of oropharynx/GI lining
why can't you use hydrogen peroxide 3% for a cat?
T/F: hydrogen peroxide 3% is a centrally acting emetic
oops! i gave WAY too much apomorphine to one of my dog patients and now he's going into respiratory distress. what can i give him to reverse the effects?
naloxone! DOES NOT reveres emetic effect
apomorphine isn't very effective in cats. what is a better choice if i need to make simba vomit?
xylazine or dexmedetomidine
why are xylazine or dexmedetomidine more effective as an emetic in a cat vs. a dog?
cats have MORE a-2 receptors and FEWER d2 receptors. it's all about receptors!!
what is the MOA of xylazine and dexmedetomidine as emetics?
i just gave comet maropitant citrate SC and he tried biting me! what gives?
give comet a break, that shit stings!
what are the two different levels that NK1 receptors work at?
blocks substance P and works at the CRTZ and peripherally the GIT
emetic center =
what is the MOA of maropitant citrate?
what two things are maropitant labeled for?
prevention in motion sickness in dogs and acute vomiting in dogs and cats
in what situation is maropitant citrate contraindicated?
bone marrow suppression w/ high doses in young dogs
what anti-emetic prokinetic, works at D2 receptors and also blocks 5-HT3 receptors?
T/F: ondansetron acts on serotonin receptors centrally AND peripherally