CV VIII Flashcards

1
Q

Where are peripheral chemoreceptors located

A

Aortic arch and carotid artery

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2
Q

What do peripheral chemoreceptors do to influence CV function

A

Sense alterations in blood-gas concentrations (O2, CO2), and changes in blood pH
Send info back to CVCC which results in change in autonomic output to return blood gas levels to normal

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3
Q

What does peripheral chemoreceptor activation change

A

Ventilation within the respiratory system
Bring in more O2 of get rid of CO2
Changes CO to transport O2

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4
Q

What is vasovagal syncope

A

Fainting in response to sudden emotional distress, sight of blood, phlebotomy (needle insertion), acute pain

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5
Q

What alters CV function in response to emotional distress

A

Hypothalamus

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6
Q

What does vasovagal syncope result in

A

Large increase in parasympathetic output (decrease CO)
Decrease sympathetic (decrease in peripheral resistance, fall in BP fails to activate baroreceptor)

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7
Q

Why do you faint in vasovagal syncope

A

Decreased CO and decrease peripheral resistance cause fall in MAP
Parasympathetic decrease in HR

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8
Q

What is bulk flow

A

Mass movement of fluid and any dissolved solutes as result of hydrostatic or osmotic pressure gradients

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9
Q

Absorption

A

If bulk flow is resulting in fluid moving into capillaries

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10
Q

Filtration

A

If bulk flow is resulting in movement of fluid out of the capillaries

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11
Q

What caused filtration

A

Hydrostatic pressure (PH)
Pressure of in blood vessels drives fluid out through pores and cell junctions

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12
Q

What causes absorption

A

Colloid osmotic pressure or on oncotic pressure

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13
Q

What is colloid osmotic pressure or oncotic pressure

A

Pressure that draws fluid in created by plasma proteins in blood

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14
Q

When is absorption zero

A

Oncotic/colloid osmotic pressure in capillary exceeds interstitial space

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15
Q

When is filtration zero

A

When hydrostatic pressure in vessels decreases as blood travels through the capillaries due to resistance encountered and exceeds interstitial hydrostatic pressure

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16
Q

What causes net filtration

A

At arterial end hydrostatic pressure exceeds colloid osmotic pressure

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17
Q

What cause absorption

A

At venous end colloid osmotic pressure exceeds hydrostatic pressure

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18
Q

Net filtration from the entire capillary network results in

A

Loss of 3L fluid/day from blood
Net pressure= hydrostatic pressure - colloid osmotic pressure

19
Q

What do lymphatic vessels assist with

A

Assist CV system with returning fluid and proteins lost through capillaries (so we don’t lose 3L/day)

20
Q

Where are lymphatic vessels

A

Associate with most capillaries through body

21
Q

What do lymphatic nodes contain

A

Immune cells

22
Q

What are lymphatic vessels composed of

A

Single endothelial layer
Large interendothelial junctions that act as one-way valves

23
Q

What causes lymphatic micro valves to open in initial lymphatic segment

A

Interstitial hydrostatic pressure is higher than inside the lymphatic

24
Q

What causes lymphatic micro valves to close and secondary valves to open

A

As fills with fluid, lymphatic hydrostatic pressure exceeds interstitial

25
Q

What does the smooth muscle of lymphatics do

A

Contracts to propel fluid one and assists one way valves in preventing back flow

26
Q

Edema

A

Abnormal accumulation of fluid in interstitial space

27
Q

What are 2 causes of edema

A
  1. Inadequate lymph drainage (obstructions within lymph nodes)
  2. Disruption in normal balance between capillary filtration and absorption (filtration>absorption)
28
Q

Velocity of blood=

A

Flow rate/c.s. Area

29
Q

Why does velocity decrease as it flow down branching vessels

A

With each branch the two new branches always have higher x-sec area then the parent vessel (together, individually smaller)

30
Q

What does the rate of blood flow affect

A

Efficiency of exchange between blood and interstitial fluid

31
Q

What does slow velocity of blood flow in capillaries ensure

A

Adequate gas and nutrient exchange

32
Q

Cv disease

A

Disorders of heart and blood vessels
Play role in 1/3 of deaths in US

33
Q

How much of US will have CV disease by 2030

A

40%

34
Q

What are uncontrolled risk factors of CV disease

A

Age, sex, family history of early CVD, genetics

35
Q

Controlled risk factors of CVD

A

Cigarette smoking, obesity, sedentary lifestyle and untreated hypertension

36
Q

What are combination of both uncontrollable and controlled risk factors

A

Diabetes, hyperlipedimia

37
Q

Atherosclerosis

A

Inflammatory process leading to hardening or narrowing of arteries

38
Q

What is contributing factor to atherosclerosis

A

Elevated blood cholesterol
Chol not readily soluble in aqueous solutions, joins lipoproteins

39
Q

Two types of lipoproteins

A

High density lipoproteins - cholesterol complexes (HDL-C) healthy
Low density lipoproteins - cholesterol complexes (LDL-C) bad cholesterol

40
Q

What are LDL-C necessary fo

A

Transport in cells, LDL-C’s proteins are digested to amino acids and freed chol used to make cell membrane and steroid hormones
But excess is brought to tissues

41
Q

What is first stage of atherosclerosis

A
  • Excess LDL brought chol + other lipids to tissues in high pressure vessels
  • taken up by endothelial cells in connective tissue layer
  • macrophages form and ingest chol and turn to foam cells
42
Q

Fatty streak of atherosclerosis

A

Macrophages cause smooth muscle cells to proliferate
- narrows lumen

43
Q

Stable fibrous plaque stage of atherosclerosis

A

Stable bubble in wall of artery
- fibrous connective tissue formed around
- Calcification, hardens wall

44
Q

What is vulnerable plaque stage

A
  • breakdown of tissue
  • clot forms where endothelial layer ruptured
  • creates blockage