CVS Lecture 19/20 - Pathophysiology of Heart Failure and Integration of CVS responses -Systems Review Flashcards
What is the definition of HF?
Syndrome which arises when the heart is unable to maintain an appropriate BP without support
What is the major organ involved in HF (apart from heart)?
Kidneys as they won’t be sufficiently perfused
What is the prevalence and incidence of HF?
P=22M worldwide, I=2M annually
What are the main causes of HF?
Arrhythmias (tachycardia), valve disease (regurgitation), pericardial disease (heart can’t pump efficently), Congenital heart disease (holes/misconnections), Myocardial disease (e.g CHD)
What are the types of cardiomyopathy?
Dilated CM, Hypertrophic CM, Restrictive CM, Arrhythmic RV CM
What is happening to HF cases?
50% of MI survivors develop HF, so deaths due to HF are increasing
How does myocardial remodelling occur (diagramatic)?
When infarct occurs, fibrous thin tissue expands, so no contraction in that tissue, then there’s late ventricular enlargement as the myocardial tissue thins due to cell slippage and there’s thinning of fibrous tissue
What is cardiomyopathy?
Heart disease in absence of known cause
What is hypertrophic CM well known for?
Commonest cause of young athletes dropping dead
How common is CM?
Occurs in 5% of HF popn
What are the causes of Dilated CM?
Idiopathic, genetic, infectious: HIV, mycobacteria; toxins and poisons: Alcohol (myocardial depressant), cocaine; drugs (chemotherapeutic agents); metabolic disorder: nutritional and endocrine deficiencies; collagen disorder, AImmuneCM, peri-partum CM, neuromuscular disorders
What are the causes of restrictive CM?
Heart is restricted so can’t dilate normally, ejection fraction can be preserved but diastolic dysfunction present - associated with hypertrophy and scleroderma and inflitrative disorders: amyloidosis and sarcoidosis
What are the causes of death in HF?
Progression of HF - ^ myocardial wall stress, retention of Na and H2O; sudden death - opportunistic arrhythmia; cardiac event (MI), other CVD event, non-CVD causes (pneumonia)
Why is adrenaline secreted during HF?
Body believes it’s bleeding to death so sympathetic drives switches on, ^ noradrenaline
Why does the kidney retain water and salt during HF?
So that Renin-Angiotensin System is switched on
Which vasoconstrictors are produced during HF?
Endothelin-1, VP, Renin/Ang, Neuropeptide Y
What are the most effective drugs in HF?
Beta blockers - block sympathetic drive
What do other drugs do in HF?
ACE inhibitors block RAS, Aldosterone receptor antagonists block aldo receptors which are high in HF
What are some diagnostic tests that can be done to check for HF?
Atrial natriuretic peptide (ANP are raised if impaired heart-released from atria) and troponin I and T
What are the important inflammatory markers for all cell types?
IL-1b, IL-6, TNFalpha which are taken up by liver and C-reactive protein, fibrinogen and serum amyloid A are released
What is the prognosis of HF?
5-yr mortality rate 50%, survival following diagnosis: men 1.7y, women 3.2y
What are the signs and symptoms of HF?
FATIGUE , orthopnea > Paroxysmal Nocturnal Dyspnoea, ^ HR (maintain CO), weak pulses, ^ Venous pressure, peripheral oedema (Na, H2O retention), crepitations, hepatomegaly and ascites
What does HF x-ray look like?
^ cardio-thoracic ratio -> heart should NOT be >50% thorax width
What is the NY heart association classification of functional capacity for patients with HF?
Reason: so you can tell patient has improved - 1=basically no symptoms and 4=patient can’t get out of chair FUNCTIONAL CLASSIFICATION
