Cytokine Profiles Flashcards Preview

Immunology Exam #2 > Cytokine Profiles > Flashcards

Flashcards in Cytokine Profiles Deck (32)
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1

What is the function of Dendritic Cells

1. use PRRs to recognize PAMPs on invaders
2. use cytokines from local area to be a "sonar" for T cells

2

T/F Cytokines released from DC cells tell T cells to express specific Cytokines

True

3

what are the 3 different cytokine profiles

Th1
Th2
Th17

4

what are the classic cytokines emitted by a Th1 T cell

TNF, IFN-y, IL-2

5

which cells do the Th1 cytokine profile activate

macrophages and NKCs

6

IFN-y tells B-cells to make which antibody

IGG

7

what is the reason a T cell would express Th1

to induce apoptosis on Bacteria or Virus infected host

8

Where are Th2 cytokine profiles normally expressed in the body

intestines

9

what are the cytokines associated with Th2 cytokine profile

IL-4, IL-5, IL-13, IL-10

10

which antibody does IL-4 tell b cells to make

IGE (to attack parasites in the intestines)

11

which antibody does IL-5 tell b cells to make

IGA (for the mucus membranes in the intestines)

12

what is the purpose of IL-10

to inhibit Th1 cytokine profile cells (to inhibit inflammation in the gut)

13

What are the 2 jobs of the helper t cell

1. remain in blood and lymph and help b cells and CTLs
2. enter battle site providing help for soldiers

14

what are the cytokines produced with the Th17 cytokine profile

IL-17, IL-21

15

what does the cytokine IL-17 attract

Neutrophils (for opsinization)

16

What type of microbe is being targeted for with the Th17 cytokine profile

fungus

17

T/F once a t cell has selected a cytokine profile he can later switch to another profile

False ( committed and limited range)

18

what is one benefit to having specific cytokines for a specific area in the body

so multiple immune responses can happen simultaneously

19

What are Superantigens

viruses and bacterial proteins that bind to specific regions of TCRs and class II MHCs

20

What is the purpose of Superantigens

to produce lots of cytokines (unregulated) and inappropriately activate t cells

21

How many signals does it take to activate Killer T cells

1

22

what is the signal coming from that can activate a Killer T cell

an activated Dendritic cell

23

What does CTL stand for

Cytotoxic T Cell | Killer T Cell | CD 8

24

T/F when the activated DC, CTL and Helper T cell get together their response is much greater

True

25

What are the 2 methods that Killer T Cells kill

1. Perforin
2. Fas Ligand

26

what does perforin do when emitted from a killer t cell

poke a hole in the target cells membrane

27

What does Granzyme B do when emitted from a Killer T Cell

initiates a chain reaction leading to target cell apoptosis

28

Does the CTL have the fas ligand or the fas protein

The Fas Ligand

29

What does the Fas protein on the target cell do when its "activated"

causes the cell to commit suicide

30

what is the co-receptor on a helper t cell

CD4