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Immunology Exam #2 > Spleen and Intestines > Flashcards

Flashcards in Spleen and Intestines Deck (39)
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1

What is the purpose of the spleen

to filter blood between artery and vein

2

what in the blood is allowed to enter the spleen

everything

3

at rest what percentage of a cardiac output goes through the spleen

5%

4

how long does it take to screen all the blood in your body by the spleen

30 minutes

5

do lymphatics bring lymph to the spleen

NO

6

what is the main cell type in the marginal sinus of the spleen

Resident Dendritic Cells

7

what do Resident Dendritic Cells do

-display MHC II
-travel to PALS and activate T cells

8

where do T cells go after they have been activated by resident dendritic cells

go to lymphoid follicles to help be cells

9

when blood first enters the spleen where is it diverted to

the marginal sinuses

10

what is the marginal sinus of the spleen loaded with

macrophages

11

eventually the blood in the spleen must filter back to which vessel

splenic vein

12

where do T cells hang out in the spleen

PALS

13

what does PALS stand for

Periarteriolar Lymphoid Sheath

14

where do B cells hang out in the spleen

in an area between the PALS and marginal sinus

15

what is the purpose of the Red Pulp in the spleen

to remove old RBCs and recycle Iron

16

is hemoglobin broken down in the spleen

yes
-globin into AAs
-Heme into bilirubin

17

T/F the spleen holds a large # of monocytes

Ture (to become macrophages or DCs)

18

What is an exampe of a MALT

GALT

19

what is an example of a GALT

Peyers Patch

20

how many Peyers Patches does the typical adult have

200

21

does the Peyers Patch have HEVs

YES

22

does the Peyers Patch have outgoing lymph

YES

23

does the Peyers Patch have incoming lymph

NOOOOOOOO

24

what cell allows antigens into the peyers patch

M cells

25

what does the M stand for in M cell (peyers patch)

Microfold

26

what does the M cell lack that makes it different from Enterocytes

Lack Villi and Mucus

27

is the M cell selective in its antigen it encloses into the peyers patch or general

Specific
-only takes in what can bind to its surface molecules

28

What are the Peyers Patches specialized in making

helper t cells that tell b cells to make IgA antibodies (Th2)

29

in the Peyers patch, what is the main cell type in the area where macrophages can eat antigens and present them

macrophages (most outer layer)

30

in the peyers patch what cells are in the area where FDC can catch and present antigens to B cells

lymphoid follicle
- B cell area