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Immunology Exam #2 > Intestinal Immunity > Flashcards

Flashcards in Intestinal Immunity Deck (25)
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1

Where in/on the body are most microbes

Skin and GI tract

2

T/F we are 10% human and 90% microbial cell

True

3

T/F we are 1% human genes and 99% microbial genes

True

4

Where in the GI do we find most microbes

Large intestine

5

T/F about 25% of fecal material is microbial stuff

False (50%)

6

What does our microbiome digest

Indigestible plant fiber (into Short Chain FAs) and provides our Colonocytes 80% of their energy

7

How do we combat C diff

Fecal Microbiota Transplant

8

Is there communication between brain-gut-enteric microbiota

YES

9

how does the brain-gut-microbiota help us

reduce anxiety, stress and depression

10

what causes production of T reg cells

Short Chain Fatty acids, Butyrate, and healthy microbes

11

What are prebiotics

Foods we can eat that promote the good flora

12

What are probiotics

Live microorganisms which when administed in adequate amounts cn=onfer a helath benefit to the host

13

what foods naturally contain good bacteria

fermented foods

14

What is a list of things our microbiome does

-competes with pathogens
-produces vitamins (k)
-digests fiber
-talks to immune system

15

Where can you find non-inflammatory macrophages

in the Lamina propria of the gut

16

what makes these special macrophages non-inflammatory

-dont release a great deal of cytokines
-use "small attacks"

17

what does secretory IgA do in the gut

-neutralize invaders
-escort them back into the lumen of the gut
-dont cause inflammation

18

why doesnt Secretory IgA cause inflammation

dont have FC heavy chain receptors (they just neutralize not opsonize)

19

T/F default in the intestines is anti-inflammatory

True

20

intestinal epithelial cells produce what

TGFbeta -> iT reg

21

what does iTreg cells produce

IL-10, TGFbeta (anti-inflammatory)

22

TLRs on DCs bind specific bacteria in the gut and produce cytokines that what

calm the immune response

23

do DCs in the gut sample the lumen directly or indirectly

Directly

24

what on DCs detect flagella on pathogens

TLR5

25

DCs produce IL-6 which drives which cytokine profile

Th17