Secondary Lymphoid Organs Flashcards Preview

Immunology Exam #2 > Secondary Lymphoid Organs > Flashcards

Flashcards in Secondary Lymphoid Organs Deck (30)
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1

What are the 2 primary lymphoid organs

Bone marrow
Thymus

2

where do B and T cells originate

Bone Marrow

3

where does the T cells develop

Thymus

4

What are the secondary Lymphoid organs

Lymph Nodes
Spleen
MALT

5

what does MALT stand for

Mucosal-Associated lymphoid tissue

6

Which lymphoid organs are Lymphoid follicles associated with

all of them

7

what is the make up of a primary lymphoid follicle

-loose network of FDCs
-rich in naive B cells (or memory cells)

8

what does FDC stand for

Follicular Dendritic Cells

9

what is the make up of a secondary lymphoid follicle

-after antigen stimulation
-turns into a Germinal Center

10

Where are dendritic cells made

in the bone marrow and migrate to tissues

11

which cells are APC

B-cells, Macrophages, Dendritic Cells

12

Who do FDCs present their "caught" antigen to

B-cells

13

What binds to invaders so DCs recognize the antigen

Complement proteins and antibodies

14

FDCs have receptors that bind to what

-complement proteins
-FC region of antibodies

15

how does the FDCs make a signal strong enough to activate a B cell

they cluster their opsonized antigens together

16

What causes a Follicle to turn into a Germinal Center

B cells activate and proliferate (doubling every 6 hours) creating a dark zone

17

When some B cells in the germinal center decide to become plasma cells where do they go

Bone Marrow

18

what process allows B cells to fine tune the Fab regions of their antibodies

Somatic Hypermutation

19

New mutations of B cells in the germinal centers are tested where

in the Light Zone

20

class switching of antibodies in the germinal center are likely to occur where

in the Dark Zone

21

T/F secondary lymphoid organs do not have seperate areas for naive T cells and naive B cells

False

22

once Helper T cells are activated they migrate where

the to B cell area to help activate the B cells

23

How can antigens enter lymph nodes

the blood or lymph

24

how do lymphocytes leave the blood and enter the lymph node

via HEV

25

what does HEV stand for

High Endothelial Venules

26

In lymph nodes, what is the major cell type in the Marginal Sinus

macrophages (APC)

27

In lymph nodes, what is the major cell type in the Cortex

-lymphoid follicle
-B cell area

28

in the lymph node, what is the major cell type in the paracortex

T cell

29

why are normal blood vessel endothelial cells difficult for Lymphocytes to pass through

they are overlaped liked shingles and offer less room for passage

30

why are HEVs easy for lymphocytes to pass through

they are columnar and offer more room for passage