Cytokines

Question 1

TNF-alpha

IL-1

Answer 1

INNATE
produced by activated MO
function: recruit PMN and MO to inflammation
vasodilation
increase vascular permeability
IL-1: induces IL-6 and IL-8

Question 2

IL-10

Answer 2

INNATE AND ADAPTIVE
produced by activated MO and Th2
function: inhibits MO cytokine production
             MHCII and co-stimulatory molecules
             inihibits viral replicaton
             increases MHC 1
            activates NK
inhibits IFN-gamma

Question 3

IL-12

Answer 3

INNATE
produced: activated MO and DCs
function: stimulate IFN-gamma
enhane CTL and NK cytolytic capabilities

Question 4

IFN alpha and beta

Answer 4

INNATE
produced: MO and many cells
function: inhibits viral replication
              increases MHCI
              activates NK

Question 5

IFN gamma

Answer 5

INNATE and ADAPTIVE
produced: Th1 and NK
function: activates MO, NK, T cells
induces MHC I and II

Question 6

IL-2

Answer 6

ADAPTIVE
produced: Th cells
function: growth for T and B cells
activates NK and MO

Question 7

IL-4

Answer 7

ADAPTIVE
produced: MO and Th2
function: differentiation Th2
class switch IgE

Question 8

IL-5

Answer 8

ADAPTIVE

produced: Th2
function: promotes growth, differentiation and activation of eosinophils and B cell differentiation

Question 9

TGF-beta

Answer 9

ADAPTIVE
produced: T cells, MO and others
function: inhibit T cell/MO activation
inhibit PMN and endothelial cells