cytokines Flashcards
(20 cards)
what does interferon do
interfere with viral replication, shield other cells so they don’t become virally infected
classified as an interleukin if mets what criteria
- Genes must be cloned
- Must be inducible in leukocytes
- Biological activity in inflammatory process must be noted
main player in IL-1
macrophages
function of IL-1
pyrogen and activate t cells
○ Also tell bone marrow to produce more phagocytic cells
○ Activate immune system
IL-1 RA
interleukin 1 receptor antagonist
-block receptor sites for IL-1
what is IL-2
T cell growth factor
- helps stimulate other t cells and responsible for autocrine stimulation (keeps them activated)
only act on cells with receptors on it
-increase NK ability to kill
what decrease IL-2
immunosuppressive cells
IL-4 and IL-5
- B cell growth factors
- Eventually aid in developing antibody production
IL-6
- Produce by all cells in the immune response
- Aid in APR production
○ Increase in inflammatory process
- Aid in APR production
IL-10
- Helps suppress immune system
- Process by T regulatory cells
interferon alpha and beta
mainly used for viral disruption
interferon gamma
○ Used to stimulate NK cells to produce LAKs
○ Aid in delay type hypersensitivity
○ Enhance immune system
IL-17
-helps increase inflammatory response
-measured in COVID
what IL is responsible for anemia of chronic inflammation
IL-17
tumor necrosis factor found on
tumor cells
-also secreted by other cells
tumor necrosis factor helps to activate
CD8 cells
-necrosis tumor
negative impacts of tumor necrosis factor
-invovled in cytokine storm killing
what gram can stimulate large amounts of tumor necrosis factor
gram - rods
-cause people to go into septic shock
septicemia with gram - rods can be deadly
colony stimulating factors produced by
stem cells in bone marrow to produce certain cells that are needed
Erythropoietin is produced in the
kidney
-in kidney failure someone can become anemic b/c won’t be producing RBC
