MHC

Question 1

MHC were first discovered on

Answer 1

WBCs

Question 2

MHC are the same thing as

Answer 2

HLA- human leukocyte antigen

Question 3

MHC is important in

Answer 3

• Important in forensics science
• Major of paternity testing
• Antigen presentation

Question 4

major role of MHC

Answer 4

present antigen to a t cell to activate the immune response

Question 5

what type of cells have MHC antigens

Answer 5

nucleated cells

Question 6

So much crossover in each alleles of MHC genes it creates

Answer 6

polymorphism

Question 7

MHC are found on

Answer 7

short arm of chromosome 6

Question 8

exert the most influence over an immune response

Answer 8

class 1 and 2

Question 9

MHC Class 1 consist of

Answer 9

A, B, C

Question 10

MHC Class 2 consist of

Answer 10

D regions (DQ, DR, and DP)

Question 11

MHC class 3 make up many

Answer 11

complement proteins and cytokines that aid in the immune system (minor function )

Question 12

MHC Class 1A:

Answer 12

580 alleles

Question 13

MHC Class 1B:

Answer 13

1000 alleles

Question 14

MHC Class 1C:

Answer 14

300 alleles

Question 15

highest expression of class 1

Answer 15

lymphs

Question 16

lowest expression of class 1

Answer 16

liver, muscle, and nerve cells
○ Mismatch on these transplants don’t matter as much

Question 17

what cells don’t have class 1

Answer 17

mature RBCs

Question 18

A and B are expressed

Answer 18

most prominently

Question 19

class 1 made up of

Answer 19

2 non-covalent bound polypeptide chains
-Alpha and beta chain: found on outer surface of cell

Question 20

Small component of Alpha 3 chain

Answer 20

extend into the cell surface

Question 21

peptide binding cleft in class 1

Answer 21

processed antigen bound here to MHC molecule
○ Antigen binding her 9 amino acid long

Question 22

Type of antigen class 1 binds to

Answer 22

altered self (endogenous), virus, fungi, etc.
* Hookup activates CD8 cells

Question 23

class 2 is mainly made up of

Answer 23

D region

Question 24

most highly expressed in class 2

Answer 24

DR

Question 25

where is class 2 typically found

Answer 25

on APC ex. macrophages, dendritic cells WILL NOT FIND ON RESTING T CELL

Question 26

structure of class 2

Answer 26

Both alpha and beta region are going to have junctions into the cell membrane peptide binding cleft deeper grove here antigen bound 12-20 amino acids long

Question 27

hookup to class 2

Answer 27

exogenous antigen -or before become endogenous antigen

Question 28

MHC class 2 presented to

Answer 28

T helper cell

Question 29

class 3 molecules make up

Answer 29

cytokines and complement proteins Found in the serum -induce opsonization, inflammation heighten immune response

Question 30

people who have DR4 at higher risk of developing

Answer 30

RA

Question 31

DQ2 and DQ8 increased risk of developing

Answer 31

diabetes -no familial inheritance

Question 32

Ankylosing Spondylitis

Answer 32

inflammatory disease creating stiffness and inflammation of the spine

Question 33

The most studied disease correlation studied for MHC

Answer 33

Ankylosing Spondylitis

Question 34

Ankylosing Spondylitis not confirmed unless someone has

Answer 34

HLA B27

Question 35

all oriental heritage never have

Answer 35

A1 and A8 gene

Question 36

more MHC in common than european descent than

Answer 36

african american

Question 37

next to ABO, ____ is most important to look at

Answer 37

MHC -start with family members

Question 38

common genes tested for HLA

Answer 38

A B DR

Question 39

MHC testing on heart transplant?

Answer 39

* Don't have time to test for this, matter of hours for a heart transplant * We only do ABO typing for this