Cytokines Flashcards Preview

USMLE Step 1 > Cytokines > Flashcards

Flashcards in Cytokines Deck (11):
1

IL-1 (aka osteoclast activating factor)

By Macros:

- Fever
- Acute inflammation
- Activates endothelial cells to express adhesion molecules
- Induces chemokine secretion to recruit WBCs

2

IL-6

By Macros:

- Fever
- Stimulates production of acute-phase proteins

3

IL-8

By Macros:

- Neutrophil chemotaxis (major)

4

IL-12

By Macros:

- T-cells into Th1 cells
- Activates NK-cells

5

TNF-alpha

By Macros:

- Mediates septic shock
- Activates endothelium
- WBC recruitment and vascular leak
- Cachexia in malignancy
- synoviocytes secrete metalloproteinase (cartilage degen)

6

IL-2

By all T-cells:

- Growth of helper, cytotoxic and regulatory T cells
- Growth of NK cells

7

IL-3

By all T-cells:

- Growth and differentiation of bone marrow stem cells (like GM-CSF)

8

Interferon-gamma (INF-gamma)

By Th1 cells: [acts via JAK[dimerization]-STAT pathway]

- Secreted by NK cells in response to IL-12 from macros
- Stimulates macrophages to kill phagocytksed pathogens
- Activates NK cells to kill virus-infected cells
- Increased MHC expression and antigen presentation by all cells

9

IL-4

By Th2 cells:

- Differentiation into Th2 cells
- Growth of B cells
- Class switching to IgE and IgG

10

IL-5

By Th2 cells:

- Differentiation of B cells
- Class switching to IgA
- Growth and differentiation of eosinophils

11

IL-10

By Th2 cells and regulatory T-cells:

- Modulates inflammatory response
- Decreases expression of MHC II and Th1 cytokines
- Inhibits activated macrophages and dendritic cells
[TGF-beta also attenuates the immune response]