HIV - DRUGS Flashcards Preview

USMLE Step 1 > HIV - DRUGS > Flashcards

Flashcards in HIV - DRUGS Deck (19):
1

PI's

-navir

2

Ritonavir

PI that inhibits p-450, thus boosting other drug concentrations (good)

3

PI AE

- Hyperglycemia, N/D, Lipodystrophy, central adiposity (buffalo hump)
- Nephropathy, hematuria (indinavir)

4

PI contraindications

Rifampin (CYP/UGT inducer) - decreasing concentrations of PI

5

NRTI: ABC

Abacavir

6

NRTI: ddl

Didanosine

7

NRTI: FTC

Emtricitabine

8

NRTI: 3TC

Lamivudine

9

NRTI: d4T

Stavudine

10

NRTI: TDF

Tenofovir
- only nucleotide NRTI

11

NRTI: ZDV/AZT

Zidovudine
- general prophylaxis and pregnancy

12

NRTI: adverse effects

- Bone marrow supression (reversed w/ G-CSF + EPO)
- peripheral neuropathy
- lactic acidosis (nucleosides)
- anemia (ZDV)
- pancreatitis (didanosine)
- hypersensitivity rxn (abacavir - assoc. w/ HLA-B*57:01)

13

NNRTI's

Delavirdine
Efavirenz
Nevirapine

14

NRTI: MOA

3 host phosphorylation --> RT inhibition and chain termination (lacks 3' OH)

15

NNRTI: MOA

No phosphorylation --> alt. site RT binding and inhibition

16

NNRTI: AE

- Rash and hepatotoxicity
- Vivid dreams and CNS Sx (efavirenz)
- contraindicated in pregnancy (delavirdine and efavirenz)

17

Raltegravir (MOA and AE)

- Reversible inhibition of integrase
- increased creatine kinase

18

Enfuvirtide (MOA and AE)

- binds gp41 (inhibits viral entry)
- skin rxn at injection site

19

Maraviroc

Binds CCR-5 on surface of T-cells/monocytes --> inhibits interaction w/ gp120