Cytokines Flashcards
(43 cards)
1
Q
characteristics of cytokines
A
- pleiotropic
- redundant
- multifunctional
2
Q
pleiotropic
A
- a particular cytokines can act on a number of different types of cells rather than a single cell type
3
Q
redundant
A
- the ability of cytokines to carry out the same function
4
Q
multifunctional
A
- the same cytokines is able to regulate a number of different functions
5
Q
four functional categories of cytokines
A
- innate immune
- adaptive immume
- chemokines that produce directed-cell migration
- hematopoiesis
6
Q
hematopoiesis cytokines
A
- IL-3
- IL-7
- G-CSF
- M-CSF
- GM-CSF
TOP 10 = 3+7
7
Q
innate immunity cytokines
A
- IFN-y
- IFN-B
- IFN-a
- TNF
- TBF-B
- chemokines
- IL-1
- IL-6
- IL-10
- IL-12
SIX LETTERS IN INNATE
ONE SEX FROM 10-12
8
Q
adaptive immunity cytokines
A
- IFN-y
- TGF-B
- IL-2
- IL-4
- IL-5
- IL-13
- IL-17
- IL-22
8 THINGS INCLUDED
9
Q
IL-1 secreted by
A
- macrophages
- endothelial cells
- some epithelial cells
10
Q
IL-1 effect
A
- endothelial cell activation (pro-inflammation)
- neutrophil activation
- FEVER
- acute phase protein synthesis
- TH17 differentiation
HOT
11
Q
IL-2 secreted by
A
- CD4 and CD8 T cels
12
Q
IL-2 effect
A
- survival, proliferation, and differentiation of effector and regulatory T cells
T
13
Q
IL-4 secreted by
A
- CD4 T cells
- mast cells
14
Q
IL-4 effect
A
- B cell switching to IgE
stE
15
Q
IL-5 secreted by
A
- CD4 T cells
- mast cells
16
Q
IL-5 effect
A
- Activation of eosinophils
steA
17
Q
IL-6 secreted by
A
- macrophages
- endothelial cells
- T cells
18
Q
IL-6 effect
A
- stimulates production of aKute phase proteins
- PROLIFERATION OF ANTIBODY PRODUCING CELLS
- steaK
Hot T-bone stEAK
19
Q
IL-12 secreted by
A
- macrophages
- dendritic cells
20
Q
IL-12 function
A
- activation of NK cells and T cells
- production of IFN-gamma
- TH1 differentiation
21
Q
interferon gamma secreted by
A
- CD4 and CD8 cells (innate and adaptive)
- natural killer cells (innate and adaptive)
22
Q
interferon gamma function
A
- activation of macrophages (innate and adaptive)
23
Q
TNF secreted by
A
- macrophages
- T cells
24
Q
TNF function
A
- endothelial cell activation (inflammation)
- action of neutrophils
- fever
- acute phase protein synthesis
- apoptosis of many cell types
BASICALLY THE SAME AS IL-1
25
IL-10 secreted by
- macrophages
- dendritic cells
- T cells
26
IL-10 function
- atTENuates inflammation (ANTI-INFLAMMATORY CYTOKINE)
- activates macrophages and dendritic cells
- inhibits IL-12 production
- decreases expression of MHC Class I and TH1 cytokines
27
TGF-beta secreted by
- CD4 cells
| - many cell types
28
TGF-beta function
- Both TGF-B and IL-10 atTenuate inflammation
- inhibition of T cel activation
- differentiation of regulatory T cells
29
Interferon alpha and beta secreted by
- virus infected cells
30
interferon alpha and beta function
- prime uninfected cells for viral defense
31
chemokines secreted by
- macrophages
- dendritic cells
- endothelial cells
32
chemokines function
- leukocyte chemotaxis
| - integrin activation
33
IL-17 secreted by
- CD4 T cells
| - other cells
34
IL-17 function
- stimulation of acute inflammation
35
IL-17 hematopoiesis
- survival and proliferation of immature B lymphocytes and T-lymphocyte precursors
- produced mainly by fibroblasts and bone marrow stromal cells
36
inflammatory cytokines
- IL-1
- IL-6
- IL-8
- TNF-alpha
37
interferon alpha and beta secreted by
- alpha: dendritic cells and macrophages
| - beta: fibroblasts
38
interferon alpha and beta function
- antiviral state
| - increase MHC class I expansion
39
examples of cytokines
- CXCL8
- CXCL2
- CCL2
- CCL21
40
CXCL8
- recruitment of neutrophils
41
CXCL2
- recruits naive T cells
42
CCL2
- helps activate and recruit macrophages
43
CCL21
- recruits naive T cells to secondary lymphoid tissues
