Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Immunology > Cytokines , receptors and signaling > Flashcards

Cytokines , receptors and signaling Flashcards

(65 cards)

Start Studying
1
Q

source of TNF

A

macrophages, T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Target of TNF

A

enothelia, epitherlia, neutrophils, hypothalamus, liver, muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Function of TNF

A

Activation (inflammation) and oxicdative burst and fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Activation (inflammation) and oxicdative burst and fever caused by

A

TNF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

IL-1 made by

A

Macrophages and endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

IL-1 targets

A

enodothelia and hypothalamus, liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

IL-1 causes

A

activation of inflammation and fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

IL-1 in the liver cauess

A

acute phase protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

IL-6 made by in

A

macrophages, endothelial cells and T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

IL-6 targets

A

Liver and B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

IL-6 causes

A

acute phase protein synt in the liver and poliferation of anitbody producing B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

IL12 made by

A

DCs and macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

IL12 target

A

T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

IL12 function

A

Increase IFN-gamma secreation, increase cytotoxic activity, Th1 differentiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

IL23 makde by

A

DCs and marcorphages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

IL-23 targets

A

T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

IL-23 promotes

A

Th17 differentiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

IL8 and other chemokines makde by

A

DCs and endothelia and T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

IL-8 and other chemokines targe

A

leukocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

IL8 funciton

A

PMN chemotaxis, leukocyte migration, DC lymph node migration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

IFN gamma and IFN betta are examples of

A

antiviral cytokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

INF alpha made by

A

DCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

INF betta made by

A

fibroblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

INF alpha tagets

A

all cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
INF alpha causes
anitiviarl immunity, increase class I MHC and activates NK cells
26
What ativates NK cells
INFalpha
27
IFN gamma (helper) made by
TH1 cells
28
INF gamma targets
macrophages and B cells
29
INF gamma
activates macrophage, isotype switching in B cells to IgG
30
IL4, IL5, IL13 make by
Th2 cells
31
IL4/5/13 target
B cells
32
IL4/5/13 cause
isotype switch to IgE
33
IL17 is from
TH17
34
IL17 target
PMNS and epithelia
35
IL17 caues
activation /mitogen for PMNs and increases antimicrobial peptides
36
TGFbetta comes from
epithelia, NK cells, Tregs, fibroblats, endothelia, others
37
TGF betta targets
T cells and B cells
38
TGF betta acts by
suppressing Th1 and Th2 devo, promotes Th17 differentiation and increaes B cell IgA isotype switching
39
What suprreses Th1 and Th2 devo
TGF betta
40
what promotes Th17 differentiation
TGFbetta
41
what increas B cell IgA isotype swithc
TGFbetta
42
what increases anitviarl immunity
INFgamma/betta
43
What activates NK cells
INFgamma
44
What couases increase in IFNgamma secreation and Th1 differentiation
IL12
45
What two things act on hypothalamus to cause fever
IL1, and TNF
46
causes isotype switching in B cells to IgG
INFgamma acting through Th1
47
IL10 source is
macrophages, DC, Th2 cells
48
IL 10 targets
macrophates, DCs and T cells
49
IL 10 functions to
inhibit IL12 produciton, reduce MHC class II and inhibit co-stim molecule expression
50
what inhibits IL12 produciton
IL10
51
What reduces MHC class II
IL10
52
What ihibits co-stim molecule expression
IL10
53
IL 2 source
Activated T cell
54
IL2 targets
autocrine activated T cells
55
IL2 function:
mitogen for activat mature niave T cells
56
IL 7 source
bone marrow stromal
57
protects body against bacteria and fungi
Th17
58
IL 7 targets
Immature T and B lymphocytes
59
IL 7 funciton
mitogen for devoi'ng immautre lymphocytes
60
IL15 and IL18 source
marcrophages
61
IL 15 and IL 18 target
NK cells
62
IL15 and IL18 function to
be a mitogen for NKcells to push for IFNgamma production.
63
G-CSF and GM-CSF source
Macros adn T cells
64
Target for G-CSF and GM-CSF
immature myeloid cells
65
function of G-CSF and FM CSF
mitogen for myloid progenitor cells, immune suppresion

Immunology (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions