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Pharmacologie > Cytotoxiques - inhibiteurs des topoisomérases > Flashcards

Cytotoxiques - inhibiteurs des topoisomérases Flashcards

1
Q

Inhibiteurs des topoisomérases de type 1

A

Irinotécan et topotécan

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2
Q

Irinotécan

A

Risque de syndrome cholinergique -> administration d’atropine en prévention

Risque de diarrhées sévères

Hématotoxicité sévère en cas d’ictère

(Métabolisé au niveau hépatique et éliminé par voie biliaire par glucuronoconjugaison)

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3
Q

Topotécan

A

Hématotoxicité : thrombopénie

Toxicité muqueuse : mucite, diarrhées

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4
Q

Inhibiteurs des topoisomérases II

A

Épipodophyllotoxines

Anthracyclines

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5
Q

Épipodophyllotoxine

A

Étoposide = VP16

EI = Hématotoxicité, alopécie, risque de leucémie secondaire (dose dpd)

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6
Q

Types d’Anthracyclines

A

Doxorubicine
Epirubicine
Idarubicine

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7
Q

EI anthracycline

A

Toxicités aiguës classiques, très alopéciantes
Cardiotoxicité dose-dpd
Risque de nécrose cutanée

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8
Q

Bléomycine - toxicité

A

Fibroses pulmonaires irréversible dose-cumulative

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Pharmacologie (20 decks)

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