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Flashcards in Day 4 Deck (20):
1

phsyiologic states of amenorrhea

pregnancy and lactation

2

structural causes of primary amenorrhea

vaginal obstruction
cryptomenorrhea
imperforate hymen
Mullerian agenesis (missing uterus and upper vagina)
uterine absence or endometrial destruction

3

gonadal causes of primary amenorrhea

Dysgenesis, 17 alpha-Hydroxylase Deficiency, Resistant Ovary (Receptor abnormalities for FSH, LH**Hypergonadotrophic hypogonadism)
Chronic Anovulation,
Testicular Feminization
PREGNANCY!!!

4

3 criteria for PCOS

1. Hyperandrogenism (elevated total or free testosterone, acne, hirsutism)
2. Chronic anovulation
3. on US looks like a string of pearls
(must meet 2 out of 3)

5

adrenal causes or primary amenorrhea

congenital adrenal hyperplasia
PCOS

6

Pituitary-Hypothalamic disorders that cause primary amenorrhea

Galactosemia (inherited deficiency of galactose converting enzymes)
Prolactin secreting pituitary tumor
Hypopituitarism
Aromatase deficiency
Delay in hypothalamic-pituitary maturation

7

enzyematic defect in cortisol pathway that causes a near blockage of cortisol depletion so there is a build-up precurosor hormone (17-hydroxy progesterone)

congenital adrenal hyperplasia

8

is the growth of hair in a typical male distribution. This hair may grow on the chin, upper lip, side of the face, breasts, lower abdomen and down medial thighs.

Hirsuitism

9

labs to get with hirsutism

Total vs. Free testosterone, Serum androstenedione, Urinary 17-ketosteroids, DHEA, DHEA-S, Prolactin, FSH, LH, Overnight Dexamethasone-Cortisol test
abdominal US for PCOS

10

most effective tx for PCOS

OCPs

11

if OCPs are working super well for PCOS what can you add

anti-androgens (spironolactone)

12

Discharge of milk or colostrom from nipple when not nursing

galactorrhea

13

how will most women w/ galactorrhea also present

amenorrhea
infertility

14

causes of galactorrhea with normal prolactin levels

OCPs

15

in primary hypogonadism what is LH level

low LH

16

how will labs with Klinefelter syndrome

high LH
low testosterone

17

pituitary abnormality w/ a lack of LH
also have an abnormality in smell (can't smell coffee)

Kallmann's syndrome

18

present w/ tender gland, palpitations, usually TSH receptor body negative. Diagnosis is made by radioactive iodine uptake and thyroid scan (there will be no uptake)

subclinical thyroiditis

19

have elevated, uniform uptake of radioactive iodine

Graves' dz

20

one nodule that is "hot"

toxic nodular goiter