Flashcards in Definitions #1 Deck (22)
most common arbovirus that is usually non-fatal and is transmitted by day biting Aedes mosquitoes
How many annual cases of Dengue?
Dengue hemorrhagic fever
more serious form of dengue viral infection that causes bleeding under the skin, frequent vomiting and abdominal pain
antibodies against one dengue serotype lead to a more severe reinfection or infection of a different serotype (complicated vaccine creation)
Symptoms of dengue
Fever, arthralgia, rash (FAR), severe flu-like symptoms
Dengue is transmitted by...
Aedes aegypti + Ae. albopictus
illness caused by Plamodium parasite and is transmitted by night biting female Anopheles mosquitoes
How many annual cases of Malaria?
Malaria is transmitted by...
Anopheles gambiae + An. arabiensis
Name the two main types of Plasmodium that cause Malaria.
P. falciparum --> 50% cases, almost all deaths
P. vivax --> 43% cases
arthropod-borne viruses that are biologically transmitted and replicate in the vector
naturally occurring bacteria found in fruit flies that decrease dengue viral population and transmission in infected flies
Wolbachia strain that inhibits DENV (Dengue) in Aedes + has low fitness cost so easier to introduce
Hoffmann et al.
Wolbachia spread through population w/ no current resistance
a.k.a. release of male insects carrying dominant lethal gene
late-acting lethal line OX513A used
a.k.a. sterile insect technique
irradiating flies w/ gamma rays to make them sterile + allow them to compete with indigenous males
bacteria that produce Cry + Cyt pore-forming toxins that lyse larval midgut epithelial cells
e.g. Bti = Bacillus thuringensis
Name the predacious mosquito larvae.
Homing endonuclease genes
genetic elements that spread by cleaving chrom.s that don't contain them and then getting copied to the broken chromo as a byproduct of the repair process
(used on X chromo to make all offspring male)