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Hematology 1 [LEC] > Description of Red Blood Cell (RBC) Abnormalities and Commonly Associated Disease States > Flashcards

Description of Red Blood Cell (RBC) Abnormalities and Commonly Associated Disease States Flashcards

(87 cards)

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1
Q

Abnormal variation in RBC volume or diameter

A

Anisocytosis

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2
Q

Large RBC (.8 mm in diameter), MCV .100 fL

A

Macrocyte

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3
Q

Large oval RBC

A

Oval macrocyte

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4
Q

Small RBC (,6 mm in diameter), MCV ,80 fL

A

Microcyte

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5
Q

Abnormal variation in RBC shape

A

Poikilocytosis

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6
Q

Small, round, dense RBC with no central pallor

A

Spherocyte

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7
Q

Elliptical (cigar-shaped)

A

Elliptocyte

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8
Q

oval (egg-shaped), RBC

A

ovalocyte

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9
Q

RBC with slit-like area of central pallor

A

Stomatocyte

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10
Q

Thin, dense, elongated RBC pointed at each end; may be curved

A

Sickle cell

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11
Q

Hexagonal crystal of dense hemoglobin formed within the RBC membrane

A

Hb C crystal

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12
Q

Fingerlike or quartz-like crystal of dense hemoglobin protruding from the RBC membrane

A

Hb SC crystal

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13
Q

RBC with hemoglobin concentrated in the center and around the periphery

A

Target cell (codocyte)

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14
Q

Fragmented RBC due to rupture in the peripheral circulation

A

Schistocyte (schizocyte)

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15
Q

RBC fragment in shape of a helmet

A

(keratocyte)

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16
Q

RBC with membrane folded over

A

Folded cell

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17
Q

Small, dense RBC with few irregularly spaced projections of varying length

A

Acanthocyte (spur cell)

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18
Q

RBC with blunt or pointed, short projections that are usually evenly spaced over the surface of cell; present in all fields of blood film but in variable numbers per field

A

(echinocyte)
Burr cell

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19
Q

RBC with a single pointed extension resembling a teardrop or pear

A

Teardrop cell (dacryocyte)

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20
Q

Hemolytic anemia

A

Anisocytosis
Diffuse basophilia
Howell-Jolly body

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21
Q

Immune hemolytic anemia

A

Spherocyte

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22
Q

Microangiopathic hemolytic anemia

A

Schistocyte (schizocyte)
microspherocytes
Helmet cell (keratocyte)

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23
Q

Extensive burns

A

Spherocyte
Schistocyte (schizocyte)
microspherocytes
Helmet cell (keratocyte)

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24
Q

Macroangiopathic hemolytic anemia

traumatic cardiac hemolysis

A

Schistocyte (schizocyte)
Helmet cell (keratocyte)

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25
Megaloblastic anemia
Anisocytosis Macrocyte Oval macrocyte Teardrop cell (dacryocyte) Basophilic stippling Howell-Jolly body Pappenheimer bodies Cabot ring
26
Iron deficiency anemia
Anisocytosis Microcyte Elliptocyte, ovalocyte
27
Myelodysplastic syndrome
Macrocyte Basophilic stippling Howell-Jolly body Pappenheimer bodies Cabot ring
28
Primary myelofibrosis
Teardrop cell (dacryocyte)
29
Myelophthisic anemia
Teardrop cell (dacryocyte) Elliptocyte, ovalocyte
30
Chronic liver disease
Macrocyte
31
liver disease, alcoholism
Stomatocyte
32
Liver disease only
Target cell (codocyte)
33
Severe liver disease (spur cell anemia)
Acanthocyte
34
Hyposplenism
Howell-Jolly body Pappenheimer bodies*
35
Postsplenectomy
Howell-Jolly body Pappenheimer bodies*
36
Bone marrow failure
Macrocyte
37
Reticulocytosis
Macrocyte
38
Anemia of chronic inflammation
Microcyte
39
Sideroblastic anemia
Microcyte Pappenheimer bodies*
40
Severe anemia; certain shapes helpful diagnostically
Poikilocytosis
41
Sickle cell anemia
Sickle cell
42
Sickle cell–b-thalassemia
Sickle cell
43
Thalassemia
Microcyte Target cell (codocyte) Teardrop cell (dacryocyte) Basophilic stippling Howell-Jolly body Pappenheimer bodies*
44
Thalassemia major
Elliptocyte, ovalocyte
45
Hb E disease
Microcyte
46
Hb C disease
Hb C crystal Folded cell
47
Hb SC disease
Hb SC crystal Folded cell
48
Hemoglobinopathies
Target cell (codocyte) Basophilic stippling Pappenheimer bodies**
49
Unstable hemoglobins
Heinz body
50
Hb H disease
Hb H
51
Hereditary
Spherocyte Elliptocyte, ovalocyte Stomatocyte
52
Rh deficiency syndrome
Stomatocyte
53
Artifact
Stomatocyte
54
Neuroacanthocytosis
Acanthocyte (spur cell)
55
abetalipoproteinemia
Acanthocyte (spur cell)
56
McLeod syndrome
Acanthocyte (spur cell)
57
Uremia
Burr cell (echinocyte)
58
Pyruvate kinase deficiency
Burr cell (echinocyte)
59
After treatment for iron, vitamin B12, or folate deficiency
Diffuse basophilia
60
Lead poisoning
Basophilic stippling
61
Glucose-6-phosphate dehydrogenase deficiency
Heinz body
62
Oxidant drugs/chemicals
Heinz body
63
Stain dark blue and are called siderotic granules when observed in Prussian blue stain
Pappenheimer bodies
64
†Cells with similar morphology that are unevenly distributed in a blood film (not present in all fields) are likely due to a drying artifact in blood film preparation; these artifacts are sometimes called crenated RBCs
Burr cell (echinocyte)
65
**new methylene blue
Supravital Stain
66
***Stain dark blue and are called siderotic granules when observed in Prussian blue stain.
67
Appearance in Supravital Stain: Dark blue granules and f ilaments in cytoplasm (seen in reticulocytes)
Diffuse basophilia
68
Appearance in Supravital Stain and Wright's stain: Dark blue-purple, fine or coarse punctate granules distributed throughout cytoplasm
Basophilic stippling
69
Appearance in Supravital Stain and Wright's stain: Dark blue-purple dense, round granule; usually one per cell; occasionally multiple
Howell-Jolly body
70
Appearance in Supravital Stain: Round, dark blue-purple granule attached to inner RBC membrane
Heinz body
71
Appearance in Supravital Stain: Irregular clusters of small, light to dark blue granules, often near periphery of cell
Pappenheimer bodies
72
Appearance in Supravital Stain: Rings or figure-eights
Cabot ring
73
Appearance in Supravital Stain: Fine, evenly dispersed, dark blue granules; imparts “golf ball” appearance to RBCs
Hb H
74
Appearance in Wright Stain: Bluish tinge throughout cytoplasm; also called polychromasia (seen in polychromatic erythrocytes)
Diffuse basophilia
75
Appearance in Wright Stain: Not visible
Heinz body Hb H
76
Appearance in Wright Stain: Irregular clusters of small, light to dark blue granules, often near periphery of cell
Pappenheimer bodies
77
Appearance in Wright Stain: Blue rings or figure-eights
Cabot ring
78
Inclusion Composed of: RNA
Diffuse basophilia
79
Inclusion Composed of: Precipitated RNA
Basophilic stippling
80
Inclusion Composed of: DNA (nuclear fragment)
Howell-Jolly body
81
Inclusion Composed of: Denatured hemoglobin
Heinz body
82
Inclusion Composed of: Iron
Pappenheimer bodies
83
Inclusion Composed of: Remnant of mitotic spindle
Cabot ring
84
Inclusion Composed of: Precipitate of b-globin chains of hemoglobin
Hb H
85
thrombotic thrombocytopenic purpura
Schistocyte (schizocyte) microspherocytes Helmet cell (keratocyte)
86
'hemolytic uremic syndrome
Schistocyte (schizocyte) microspherocytes Helmet cell (keratocyte)
87
disseminated intravascular coagulation
Schistocyte (schizocyte) microspherocytes Helmet cell (keratocyte)

Hematology 1 [LEC] (25 decks)

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