Flashcards in Development of the Nervous System Deck (25)
When does human brain development begin?
3rd week post conception
The intra-uterine environment is important for neurological development. What are some examples of insults here which may be continuous throughout pregnancy?
Alcohol exposure and CMV infection
What is the embryonic period of neurological development?
Conception to 8 weeks
Which part of the embryo becomes us? Which part evolves into the placenta and cord?
Us = epiblast, placenta and cord = hypoblast
What is the first defined neural structure to form? When does this occur?
Neural tube- 20-27 days
What will the hollow centre of the neural tube go on to become?
Ventricular system and the central channel of the spinal cord
What will the anterior/rostral parts of the neural tube go on to become?
What will the caudal part of the neural tube go on to become?
If the neural tube does not close at the bottom, what can this result in?
Spina bifida or neural tube defect
High concentration of Pax6 with low concentration of Emx2 induces progenitors to differentiate into what?
Low concentration of Pax6 with high concentration of Emx2 induces the formation of what neurones?
Visual cortex neurones
What defines the foetal period of neurological development?
9 weeks to term
When is the primary sulci of the brain formed?
When is the secondary sulci of the brain formed?
When is the tertiary sulci of the brain formed?
36 weeks +
What is the function of axons?
Transmit signals from neurones
What is the function of dendrites?
Transmit information to neurones
When does myelination occur?
Physical maturation is adolescence is due to what? Do these act on the brain?
Gonadal hormones- they act on the brain as the brain has many steroid receptors
What hormone makes girls more prone to stress?
What hormone makes boys less prone to stress?
What does the PLP1 gene encode?
A transmembrane protein, the predominant myelin protein
The PLP1 gene is located where?
Pelizaeus-Merzbacher disease occurs because of a mutation where?