Diabetes: pharmacokinetics, dosages, adverse reactions Flashcards
(31 cards)
considerations for oral therapy in patients with T2DM
page 225
ADA algorithm for treatment
page 226
sulfonylureas pharmacokinetics
page 227
sulfonylurease dosages
page 228
sulfonylureas adverse reactions
- CV: edema, syncope
- DERM: rash, urticaria, pruritis, photsensitivity
- EENT: blurry vision
- ENDO: hypoglycemia, hyponatremia
- GI: anorexia, N/V, diarrhea, gas, heartburn, constipation
- HEM: aplastic anemia, hemolytic anemia, bone marrow depression, thrombocytopenia, agranulocytosis
- MISC: disulfiram-like reaction especially if patient drinks alcohol
- MS: arthralgia, leg cramps, myalgia, tremors
- NEURO: anxiety, depression, dizziness, headache, insomnia
- RENAL: minor diuretic effect
metformin pharmacokinetics
page 229
dosing of metformin and metformin combinations
page 229
metformin adverse reactions
- GI: abdominal pain, nausea, diarrhea, bloating, metallic taste
- META: hypoglycemia, lactic acidosis (rare)
- higher risk of lactic acidosis with renal dysfunction, increased age, DM, HF, other conditions having risks for hypoperfucion and hypoxemia
- MISC: decreased B12 levels
meglitinide dosages
page 230
meglitidine pharmacokinetics
page 230
meglitinide adverse reactions
page 230
TZD pharmacokinetics
page 231
TZD dosages
page 231
TZD adverse reactions
page 232
alpha-glucosidase inhibitor pharmacokinetics
page 232
alpha-glucosidase inhibitor dosage
page 232
alpha-glucosidase inhibitor adverse reactions
page 233
amylin analogue pharmacokinetics
page 233
amylin analogue dosage
page 233
amylin analogue adverse reactions
page 234
GLP-1 agonists pharmacokinetics
page 234
GLP-1 agonists dosage
page 234
GLP-1 agonists adverse reactions
page 234
DDP-IV pharmacokinetics
page 235
