psych: pharmacokinetics, dosages, adverse reactions Flashcards
(45 cards)
1
Q
phenothiazine adverse reactions
A
- CV: dizziness, fainting, ortho hypotension, tachycardia
- DERM: photosensitivity
- EENT: blurry vision, increased IOP, mydriasis, retinal pigmentation
- ENDO: hyperglycemia, weight gain, impaired thermoregulation
- GI: dry mouth, constipation, jaundice
- GU: decreased libido, decreased ejaculation, urinary retention
- NEURO: EPS, impaired memory
2
Q
phenothiazines pharmacokinetics
A
page 271
3
Q
phenothiazine dosages
A
page 271
4
Q
atypical antipsychotic pharmacokinetics
A
page 273
5
Q
atypical antipsychotic dosages
A
page 273
6
Q
atypical antipsychotic adverse reactions
A
- CV: Risperdal causes dose related hypotension and reflex tachycardia; clozapine causes ortho hypotension, tachycardia, and myocarditis; quetiapine causes palpitations and postural hypotension
- GI: N/V
- GU: sexual dysfunction (risperidone)
- HEM: clozapine (agranulocytosis)
- MISC: weight gain, hypersalivation (clozapine); risperidone may effect sleep
- NEURO: headache, insomnia, dizziness, akinesia, somnolence, EPS, NMS
*
7
Q
MAOIs pharmacokinetics
A
page 277
8
Q
MAOI dosages
A
page 277
9
Q
MAOI adverse reactions
A
- EENT: dilated pupils
- GU: sexual dysfunction
- NEURO: HYN crisis, serotonin syndrome
- MISC: weight gain
10
Q
TCA pharmicokinetics
A
page 278
11
Q
TCA dosages
A
page 278
12
Q
adverse reactions of TCAs
A
page 278
13
Q
SSRI pharmacokinetics
A
page 280
14
Q
SSRI dosages
A
page 280
15
Q
SSRI adverse reactions
A
- GI, nausea, diarrhea
- GU: anorgasmia in men and women and ejaculatory disturbances in men
- NEURO: agitation, headache, insomnia, nervousness, sedation, tremor, SEROTONIN SYNDROME
16
Q
SNRIs pharmacokinetics
A
page 281
17
Q
SNRI dosages
A
page 281
18
Q
SNRI adverse reactions
A
- CV: increase of 10-15 inDBP, diaphoresis
- DERM: increased sweating, pruritus, rash
- EENT: blurred vision, increased IOP
- GI: nausea, dry mouth, constipation, anorexia, increased liver enzymes
- GU: ejaculatory disturbances, erectile dysfunction, decreased libido, urinary hesitation
- NEURO: tremor, seziures, fatigue, drowsiness, insomnia, headache
19
Q
wellbutrin pharmacokinetics
A
page 282
20
Q
wellbutrin dosages
A
page 282
21
Q
clinical uses of wellbutrin asie from depression
A
- smoking cessation (Zyban only)
- off label treatment of adult ADHD
- short term management of anxiety
- increase sexual desire in women
22
Q
trazadone pharmacokinetics
A
page 283
23
Q
trazadone dosing
A
page 283
24
Q
trazadone adverse reactions
A
- CV: ortho hypotension for 4-6 hours after dose
- GI: mild n/v
- GU: priapism
- NEURO: drowsiness
25
remeron pharmacokinetics
page 283
26
remeron dosing
page 283
27
remeron adverse reaction
* GI: weight gain, dry mouth, increased appetite, n/v
* MISC: flu-likesymptoms and abnormal dreams
* NEURO: sedation
28
lithium pharmacokinetics
page 284
29
lithium dosing
page 285
30
lithium adverse reactions
page 285
31
dosing of depakote
page 286
32
depakote adverse reactions
* SERIOUS: severe hepatic and pancreatic toxicity and thrombocytopenia
* LESSER: weight gain, transient alopecia, drowsiness, nausea, abdominal pain, agitation, dizziness, headache, rashes, irregular meses, and tremors
33
uses of carbamazepine (Tegretol)
anticonvulsant
antimanic
antineuralgic
antipsychotic
34
tegretol mechanism of action
decreases sodium and calcium ion influx into neuronal membranes, thus reducing their potnetiation ability
35
abrupt withdrawal of tegretol may cause
status epilepticus
36
labs that must be monitored with Tegretol
CBC (aplastic anemia)
LFTs
serum drug levels
37
what is the last resort anxiolytic agent
tegretol
38
typical antipsychotics used to treat bipolaar mania
Zyprexa
Abilify
39
agents used to treat anxiety disorders
benzodiazepines
40
when are benzo's particularly useful
acute situation anxiety and adjustment disorder where therapy is expected to be less than 6 weeks
41
benzo mechanism of action
depress all levels of the CNS by enhancing the action GABA
enhanced GABA decreases neuronal excitation, thereby causing the anxiolytic effect
42
clinical uses of benzos
anxiety
anticonculsant
muscle relaxer
adjuvant for anethsethia
treatment of alcohol addiction and withdrawal
43
example of benzos
alprazolam (Xanax)
chlordiazepoxide (Librium)
clonazepam (Klonopin)
clorazepate (Tranxene ER)
diazepam (Valium)
lorazepam (Ativan)
oxazepam (Serax)
triazolam (Halcion)
44
benzo adverse reactions
page 288
45
