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Pharmacology > endocrine disorders pharmacokinetics/adverse reactions/dosage > Flashcards

endocrine disorders pharmacokinetics/adverse reactions/dosage Flashcards

1
Q

cinacalcet adverse reactions

A
  • CV: arrythmias, chest pain
  • GI: vomiting, diarrhea
  • MS: muscle aches/cramps, sudden tightening of muscles in hands, feet, face, throat
  • NEURO: dizziness, weakness, burning, tingling, unusual feeling in lips, tongue, fingers, or feet, seizures
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2
Q

vasopressin adverse reactions

A
  • CV: MI, diaphoresis
  • DERM: rash, skin blanching, pallor
  • GI: N/V, diarrhea
  • NEURO: dizziness
  • MISC: anaphylaxis, pain at injection site, water intoxication
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3
Q

desmopressin adverse effects

A
  • CV: acute MI, thrombosis, facial flushing, edema, HTN, palpitations
  • EENT: rhinorrhea/nasal congestion from nasal spray
  • GI: abdominal cramps, nausea
  • GU: decreased urination
  • META: water intoxication, rapid weight loss
  • NEURO: agitation, coma, headache, insomnia, confusion, seizures
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4
Q

Syntroid, Levoxyl, unithroid pharmacokinetics

A

page 200

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5
Q

Synthroid, Levoxyl, Unithyroid (T4)

adverse reactions

A
  • CV: tachycardia
  • DERM: urticaria
  • META: heat intolerance
  • NEURO: tremors, rash
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6
Q

liothyronine

(Cytomel, Triostat)

pharmacokinetics

A

page 201

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7
Q

T4 dosage

A

50mcg initially

may be increased every 2-3 weeks

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8
Q

liothyronin dosage

A

5mcg/day

may increase by 5-10mcg/week

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9
Q

liothyronine maintenance dose for myxedema goiter

A

75 mcg daily

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10
Q

liothyronine adverse reactions

A
  • CV: arrythmias, tachycardia
  • DERM:reversible hair loss in children at begining, dry skin, rash, hives
  • GI: intolerance
  • NEURO: headaches
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11
Q

dosage of liotrix

A

50/12.5 mcg then double every month until desired results are achieved

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12
Q

liotrix adverse reactions

A
  • CV: CARDIOVASCULAR COLLAPSE, arrythmia, tachycardia, HTN
  • DERM: increased sweating
  • ENDO: hyperthyroidism, menstrual irregularities
  • GI: N/V, cramps
  • META: weight loss, heat intolerance
  • MISC: accelerates bone maturation in children
  • NEURO: insomnia, irritability, nervousness, headache
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13
Q

PTU pharmacokinetics

A

page 204

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14
Q

PTU dosage guidelines

A

page 204

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15
Q

PTU adverse reactions

A
  • DERM: hair loss, pruritis, rash, skin pigmentation, urticaria
  • GI: nausea
  • HEM: agranulocytosis can occur as long as 4 months after therapy and can cause fatal hepatitis
  • MISC: lupus-like syndrome
  • NEURO: headache, paresthesia
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16
Q

methimazole pharmacokinetics

A

page 205

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17
Q

dosing of methimazole

A

start with 15-60mg as single or divided doses for 6-8 weeks

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18
Q

cinacalcet pharmacokinetics

A

page 207

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19
Q

calcitrol pharmicokinetics

A

page 208

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20
Q

calcijex dosage/administration

A

injection 0.5-4mcg every other day

21
Q

rocaltrol dosage/administration

A

PO: 0.25-1mcg/day

22
Q

calcitrol adverse reactions

A
  • CV: arrythmias
  • GI: constipation, metallic taste, nausea
  • META: hypercalcemia, polyuria
  • NEURO: headach, irriability
23
Q

vasopressin pharmacokinetics

A

page 209

24
Q

vasopressin dosage guidelines

A

page 209

25
Q

oxytocin pharmacokinetics

A

page 210

26
Q

oxytocin adverse reactions

A
  • CV: tachycardia, premature ventricular contractions, hypotension (mom and baby)
  • EENT: neonetal retinal hemorrhage
  • GI: N/V in both
  • MISC: prolonged IV infusion has caused severe water intoxication with seizures, coma, and death
  • OB/GYN: postpartum hemorrhage in mother
27
Q

desmopressin pharmacokinetics

A

page 210

28
Q

desmopressin (DDAVP, stimate) dosage information

A

page 210

29
Q

lypressin pharmacokinetics

A

page 211

30
Q

lypressin dosing

A

nasal spray, 1-2 sprays per nostril QID

(adults and children over 12)

31
Q

lypressin adverse reactions

A
  • CV: chest tightness, SOB, dyspnea
  • EENT: eye pain/irritation, itching, irritation or sores inside nose, runny/stuffy nose
  • GI: abdominal/stomach cramps, increased BM, heartburn
  • NEURO: coma, confusion, convulsions, drowsiness, headache, weight gain, problems with urination
32
Q

Actual practice dosage of lypressin

A

ranges from 1 spray at bedtime to 10 sprays every 3-4 hours

33
Q

adverse reactions of somatrem and recombinant somatropin

A
  • CV: edema of hands anf feet
  • ENDO: hypoglycemia, hypothyroidism, insulin resistance
  • MISC: pain at injection site
34
Q

pharmacokinetics of octreotide (Sandostatin)

A

page214

35
Q

dosage of octreotide (Sandostatin)

A

page 214

36
Q

octreotide (Sandostatin)

adverse reactions

A
  • CV: sinus bradycardia, arrhythmias
  • ENDO: hypothyroidism
  • GI: gallbladder abnormalities (stones and biliary sludge), diarrhea, N/V, abdominal discomfort, gas, distention, constipation
  • META: hypoglycemia or hyperglycemia can develop in acromegaly patients
37
Q

glucocorticoid pharmacokinetics

A

page 215

38
Q

glucocorticoid mechanism of action:

glucose metabolism, inflammation/immune function, other effects

A

page 215

39
Q

glucocorticoids adverse reactions

A
  • CV: tachycardia
  • DERM: acne, delayed wound healing, facial flushing
  • ENDO: hyperglycemia, cushings syndrome
  • GI: abdominal distention, diarrhea, constipation, heartburn, increased appetite, peptic ulcers, GI bleeds
  • MISC: increased susceptibility to infections, allergic reactions
  • NEURO: anxiety, insomnia, mood swings, hallucinations, depression
40
Q

fludrocortisone (Florinef) pharmacokinetics

A

page 217

41
Q

fludrocortisone (Florinef dosage

A

page 217

42
Q

fludrocortisone adverse reactions

A
  • DERM: acne
  • GI: ulcers, increased appetitie, abdominal distention, upset stomach, vomiting
  • META: cold, unusual hair growth
  • MISC: potential for decreases in inflammatory and immune responses, weight gain, swollen limbs
  • NEURO: dizziness, headaches, exaggerated sense of well-being, insomnia, mood swings, depression, anxiety
43
Q

aminoglutamide (Cytadren)

pharmacokinetics

A

page 218

44
Q

aminoglutamide (Cytadren) dosage

A

page 218

45
Q

aminoglutethimide (Cytadren)

adverse reactions

A
  • GI: nausea, anorexia (first few weeks)
  • NEURO: drowsiness, dizziness, headache, weakness
46
Q

anastrozole (Arimedex)

pharmacokinetics

A

page 219

47
Q

anastrozole (Arimedex) dosage

A

page 219

48
Q

anastrozole (Arimedex)

adverse reactions

A
  • CV: peripheral edema
  • GI: N/V
  • GYN: vaginal bleeding, hot flashes
  • MISC: flu syndrome, cataracts
  • MS: fracture, sore muscles, fatigue, accidental injuries
  • NEURO: mood disturbances
49
Q
A

Pharmacology (28 decks)

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