Diabetes type 2 Flashcards Preview

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Flashcards in Diabetes type 2 Deck (20)
1

In what 3 forms is energy found in the body?

Glycogen in the muscles
Glycogen in the liver
Free glucose
Fat

2

By which receptor does glucose enter the cell?

GLUT2

3

What causes K channels to close?

Increased ATP levels

4

What opens Ca++ channels?

Cell depolarisation due to less K+ ions

5

What happens when Ca++ levels?

Causes release of insulin from insulin granules

6

In which cells of the body does insulin release occur?

Beta cells in pancreas

7

What is insulin required for?

Lipolysis
Glucose production in liver
Glucose uptake in muscle

8

What are the core defects of type 2 diabetes?

Insulin resistance
B cell dysfunction

9

What causes insulin resistance?

Both cctopic fat accumulation and
increased CRP lead to inhibition via serine kinases

10

True or False
PCOS is related to DM2

True

11

True or False
Foetal malnutrition is linked with DM 2

True

12

True or False
Ehlers Danlos syndrome has a link to DM2

False

13

True or False
Apple shaped people are more likely to develop DM2

False.
Pears more likely.

14

Why can microvascular neuropathies occur before diagnosis?

Often have diabetes 2 for 10 years before diagnosis

15

What kind of complications can be present in DM2?

Retinopathy
Neuropathy
Erectile dysfunction
Nephropathy

16

What waist:hip ratio has an increased CV risk in women and in men?

Women: >0.85
Men : >0.9

17

How common is gestational diabetes?

5% of pregnant women

18

What HbA1c is target in pregnancy?

43mmol/L

19

Which drug can be used safely in pregnancy?

Metformin
Glibenclamide

20

Which HLA type makes type 2 more likely?

HLA-DR
HLA-DQ