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Flashcards in Pituitary Deck (85)
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1

What hormone is in excess in Cushing's syndrome?

Cortisol

2

What hormone is in excess in Cushing's syndrome?

Cortisol

3

Which hormone pre-empts cortisol production?

ACTH

4

Where does ACTH come from?

Anterior pituitary

5

What characterises Cushing's syndrome?

Moon shaped face
Buffalo hump
Central obesity
Frontal balding in women
Proximal myopathy
Striae

6

True or False
Osteoporosis is associated with Cushings

True

7

True or False
Hypertension is associated with Cushings

True

8

True or False
Decreased appetite is associated with Cushing's

False
Increased!

9

How is Cushing's tested for?

High dose exogenous oral steroid should lead to low serum cortisol

10

What values are expected in a positive Cushing's test?

>100nmol/L is abnormal.

11

What other test can be done to measure cortisol?

24hr urine collection.

12

What values are expected in the 24hr urine collection?

Less than 250 is normal

13

What diurnal variation is present with cortisol?

Drops at midnight.
Peaks at 9AM

14

What is the definitive test for Cushing's?

2 day 2mg/day dexamethosone

15

What value indicates a negative result in the definitive test?

More than 500

16

What is the main cause of Cushing's syndrome?

Pituitary gland dysfunction

17

A cancer of where can also simulate Cushing's?

Adrenal glands.
Usually an adenoma

18

What is the treatment for Cushing's?

Removal of hypothalamus (hypophysectomy)

19

What drug treatments can be given for Cushing's syndrome?

Metyrapone
Ketoconazole

20

What is an important factor to remember about ketoconazole?

Hepatotoxic

21

What is Pan Hypopituitarism?

failure of both anterior and posterior pituitary to produce hormones

22

What happens when the posterior pituitary is insufficient?

Diabetes Insipidus

23

What is the most common cause of hypopituitarism?

Pituitary tumours

24

True or False
Menstrual irregularities are a sign of anterior hypopituitarism

True

25

True or False
Excessive sweating is a sign of anterior hypopituitarism

False.

26

True or False
Loss of facial and pubic hair is a sign of hypopituitarism

True

27

True or False
Growth retardation is a sign of anterior hypopituitarism

True

28

If there was an excess of GH before puberty what would be the result?

Giantism

29

What is the Synacthen test?

ACTH stimulation

30

Which hormone pre-empts cortisol production?

ACTH