Flashcards in Diabetic Nephropathy Deck (6)
What is the pathogenesis of diabetic nephropathy?
Hyperglycemia direct damages the glomerulus
Glucose also results in the creation of ROS which cause damage
Creation of an inflammatory state that promotes atherosclerosis and impacts renal hemodynamics
ECM accumulation, GBM thickening, glomerulosclerosis
Effect of ACEi/ARBs on glomerulus
Reduce vasoconstriction and glomerular pressure (act on the efferent arteriole)
This will transiently decrease the GFR but in the long term it is a good thing and is protective
Block the sodium glucose linked cotransporter in the PCT
Reduce the amount of Na and glucose that is reabsorbed into the blood
UTI is a side effect
Positive impacts on CV outcomes
Slow progression of diabetic nephropathy
In diabetes is BP or sugar control more important?