Transplant Part 1 Flashcards Preview

Week 50: CKD > Transplant Part 1 > Flashcards

Flashcards in Transplant Part 1 Deck (7)
Loading flashcards...
1

5 contraindications to receiving a transplant

Active infections
Active malignancy
Active psychiatric illness
Unacceptably high perioperative risk (unrevascularizable CAD)
High burden of comorbid conditions (dementia, end stage lung/heart disease)

2

Why is a living donor transplant the best option?

Shortest time to transplant (compared to deceased donor wait time)
Lowest perioperative risk
Better graft longevity

3

Expanded criteria for a deceased donor

Donors are older, may have more comorbidities (DM, HTM)
The kidneys wont last as long but they will work - better than no kidneys

4

Donation after cardiac death

Not fully technically brain dead, have to take off life support and wait
Perfusion can be really low for a long time - can ruin the organs
50% will still need some dialysis in the first week

5

2 immune mechanisms of graft rejection

T cell mediated (cellular rejection - acute rejection - can treat this well)
B cell mediated (Ab mediated rejection - long term - cannot treat this well)

6

Hyperacute rejection is caused by....

Antibodies
Ab to the HLA molecules on the donor kidney

7

4 circumstances where you can get exposed to foreign HLA and make Abs

Pregnancy
Blood transfusion
Transplantation
Infection