Diazepam (Valium) Flashcards Preview

Paramedic Drugs Set 7 - Sedatives / Paralytics > Diazepam (Valium) > Flashcards

Flashcards in Diazepam (Valium) Deck (7)
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1

Classification

Benzodiazepine

2

Mechanism of Action

  • Binds to benzodiazepine receptors & enhances the effects of GABA.
  • Acts at the level of the limbic, thalmic, & hypothalmic regions of the CNS and can produce any level of CNS depression (including sedation, muscle relaxation, anticonvulsant activity)

3

Indications

  • Anxiety
  • Skeletal muscle relaxation
  • Alcohol withdrawal
  • Seizures
  • Sedation for cardioversion

4

Contraindications

  • Acute-angle glaucoma
  • CNS depression
  • Alcohol intoxication
  • Known sensitivity

5

Adverse Effects

  • Respiratory depression
  • Drowsiness, fatigue
  • Headache, nausea
  • Confusion, oversedation
  • Hypotension

6

Administration

  • Anxiety
    • Adult: 
      • Moderate: 2-5 mg slow IV/IM
      • Severe: 5-10 mg slow IV/IM
    • Peds: 0.04-0.3 mg/kg/dose IV/IM every 4 hours (max 0.6 mg/kg)
  • Delirium Tremens from Acute Alcohol Withdrawal
    • Adult: 10mg 
  • Seizure
    • Adult: 5-10 mg slow IV/IO every 10-15 minutes, max 30 mg.
    • Peds: Refer length-weight-based chart
  • Premedication before Cardioversion
    • Adult: 5-15 mg

7

Special Considerations

  • Extravasation of diazepam causes tissue necrosis.
  • Diazepam is insoluble in water and must be disolved in propylene glycol. This produces a viscous solution. Give slowly to prevent pain on injection.