Diseases of muscle Flashcards Preview

Clinical Pathology > Diseases of muscle > Flashcards

Flashcards in Diseases of muscle Deck (10):
1

Muscle fibre components

Basal lamina, plasma membrane, mitochondria, sarcoplasmic reticulum, myofibrils, myonuclei

2

Functional systems

Ion fluxes, neuromuscular transmission, excitation-contraction coupling, oxidative phosphorylation, mRNA transport

3

Muscle disease symptoms

(Limited) Wasting, pain, cramping, fasciculations, weakness

4

Clinical investigations

Clinical, electromyograph, nerve conduction studies, MRI, serum/blood investigations

5

Biological basis

Nerves, motor end plates primary (myopathies - destructive and non-destructive)

6

Classification

1. Diseases of the Sarcolemma & Extracellular Matrix
2. Diseases of Myonuclear Abnormalities
3. Diseases of Myofibrillar & Internal Cytoskeletal Proteins
4. Diseases of Ion Channels (Channelopathies)
5. Myopathies based on complex molecular defects
6. Developmental diseases
7. Disorders of catabolic mechanisms
8. Defects of neuromuscular transmission
9. Metabolic defects
10. Dysimmune & infectious myopathies
11. Toxins & Iatrogenic disorders
12. Chronic denervation
13. Endocrine disorders

7

Sites for biopsy

Frontalis, pectorales, quadriceps, biceps, tibialis anterior, deltoid

8

Where is most commonly biopsy?

Quadriceps - accessible and not traumatic

9

Muscle biopsy

Snap frozen - mitochondrial enzymes

Frozen - routine histochemistry and IHC, stored/referred

Glutaraldehyde - EM

Formalin - Morphology and IHC

10

Sarcolemma

The basal lamina

Decks in Clinical Pathology Class (60):