Flashcards in diseases of the motor unit Deck (54)
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1
fasciculations are a feature of LMN or UMN
LMN lesion
2
motor functional deficits that define neuromuscular disorders
distribution, weakness, atrophy, cramps
3
sensory functional deficits that define neuromuscular disorders
distribution, parasthesias, dysthesias
4
bulbar involvement may be indicated by what sx?
dysphagia, dysarthria
5
myopathy or neuropathy: presents more commonly with proximal muscle weakness
myopathy
6
distal muscle weakness
neuropathy
7
presents with mixed LMN and UMN lesion signs
ALS
8
ALS affects which portions of SC (2)
1. anterior horn
2. corticospinal tract
9
weakness, atrophy, fasciculations, spasticity, hyperreflexia; sparing sensory fxn
ALS
10
what does ALS typically spare (4)
1. cognition
2. EOM
3. sphincters
4. CSF
11
dx of ALS: UMN + LMN lesion signs in _____region + ____spinal regions OR ____spinal regions
bulbar region+2 spinal regions OR
3 spinal regions
12
20% of ALS patients have what gene mutation
SOD
13
glutamate antag, with 2-3 month prolonged survival in ALS
riluzole
14
individual disorder of single nerve; typically cause by ____(3)
mononeuropathy; caused by trauma, entrapment, compression
15
multifocal mononeuropathies; typically caused by_____
mononeuritis multiplex; caused by vasculitis
16
neuropathic pain following nonpainful stimuli
allodynia
17
unpleasant sensation that is either spontaneous or evoked by pressure/movement/touch
dysesthesia
18
heightened pain sensation provoked by painful stimulus
hyperalgesia
19
irritating spontaneous sensation
parasthesia
20
stocking glove neuropathy with distal weakness
peripheral neuropathy
21
pes cavus, distal muscle weakness/wasting in legs, difficulty walking
charcot-marie-tooth disease
22
what is the most common inherited neuro disorder
charcot-marie-tooth disease
23
another name for charcot-marie-tooth disease
hereditary motor sensory neuropathy
24
type ____HSMN is demyelinating with ____NCV
type 1; slowed NCV
25
type _____HSMN is axonal with _____NCV
type 2; normal or mildly slowed NCV
26
ascending paralysis comes on over days-weeks; spared sensory; loss of DTR; high alb with nml WBC
acute inflammatory demyelinating neuropathy (guillain barre)
27
opthalmoplegia + ataxia + loss of DTR
fisher syndrome
28
most common cause of acute, nontraumatic generalized paralysis in young adults
guillain barre
29
gold standard tx for guillain barre
plasmapharesis
30
