Diuretics

Question 1

➢ General site of action is the nephron structure in the kidney.

➢ Increases urine formation and output resulting in net loss of H2O from the body and decreased BP.

Answer 1

DIURETICS

Question 2

A potent diuretic that results in substantial fluid loss because it Inhibits Na+ and Cl reabsorption in the loop of Henle and so H20.

Dilated blood vessels & treats edema associated with CHF & hepatic/renal disease

Answer 2

LOOP DIURETICS

Question 3

Example of Thiazide

Answer 3

• Hydrodiuril
• Zaroxolyn

Question 4

It inhibits the sodium – chloride transporter in the distal tubule. It affects the excretion of Na+, Cl-, K+, and H2O without altering pH.

For the treatment of edema

Answer 4

THIAZIDE

Question 4

Examples of Loop Diuretics

Answer 4

*Furosemide
*Torsemide
*Bumetanide

Question 4

➢ Antagonized the actions of aldosterone at the distal segment of the distal tubule

➢ Causes more sodium and water to pass into the collecting duct and be excreted in urine.

Answer 4

POTASSIUM SPARING DIURETICS

Question 4

Potassium Sparing Diuretic Prototype

Answer 4

ALDACTONE

Question 5

➢Inhibits the action of the enzyme carbonic anhydrase.

➢ Important for the excretion of hydrogen.

➢ It slows down the movement of hydrogen ions which leads to greater amount of sodium and bicarbonate lost in the urine

Answer 5

CARBONIC ANHYDRASE INHIBITORS

Question 6

It is most often used for the treatment of Glaucoma and is used as adjunct to other diuretics when more
intense diuresis is needed.

Answer 6

CARBONIC ANHYDRASE INHIBITORS

Question 6

This type of diuretic exerts their therapeutic effect by pulling water into the renal tubule without loss of sodium.

Answer 6

OSMOTIC DIURESIS

Question 7

One and only example of osmotic diuresis

Answer 7

MANNITOL

Question 8

Give the 5 Diuretics

Answer 8

1. Loop diuretics
2. Thiazide
3. Potassium sparing diuretics
4. Carbonic anhydrase inhibitors
5. Osmotic diuresis