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Flashcards in Diuretics Deck (24):
1

Major site of NaCl and NaHCO3 reabsorption (60-70%)

PCT

2

Carbonic anhydrase inhibitors

Acetazolamide, dorzolamide, brinzolamode, dichlorphenamide, methazolamide

3

Used in mountain sickness

Acetazolamide

4

Loop diuretics

Furosemide, bumetanide, torsemide, ethacryonic acid

5

MOA of loop diuretics

Inhibit Na/K/2Cl transporter in thick ascending loop of Henle

6

Loop diuretics toxicities

OH DANG
Ototoxicity
Hypokalemia
Dehydration
Allergy to sulfa
Nephritis
Gout

7

Thiazide diuretics

Hydrochlorothiazide, chlorthalidone, indapamide, metolazone

8

MOA of thiazides

Inhibit Na/Cl teansporter in DCT

9

SE of Thiazide diuretics

HYPER GLUC
Hyper - glycemia, lipidemia, uremia, calcemia

10

Potassium-sparing diuretics

STAE
Spironolactone
Triamterene
Amiloride
Eplerenone

11

Site of action of spironolactone

Cortical collecting ducts

12

MOA of spironolactone

Steroid inhibitor of cytoplasmic aldosterone receptor in cortical collecting ducts
Reduce K excretion

13

MOA of Amiloride and Triamterene

Inhibit ENaC (epithelial sodium channels) in cortical collecting ducts, reduces Na reabsorption and K excretion

14

Spironolactone uses

Hyperaldosteronism
Hypertension
Heart failure
Hypokalemia

15

SE of spironolactone

Hyperkalemia
Gynecomastia
Impotence
BPH
Hyperchloremic metabolic acidosis

16

Drugs that can cause gynecomastia

Some Drugs Create Awesome Knockers
Spironolactone
Digoxin
Cimetidine
Alcohol
Ketoconazole

17

Osmotic diuretics

Mannitol
Glycerin
Isosorbide
Urea

18

Uses of mannitol

Rhabdomyolysis
Hemolysis
Increased ICP
Acute glaucoma

19

ADH agonists

Desmopressin

20

ADH antagonists

Conivaptan
Tolvaptan
Lixivaptan
Demeclocycline
Lithium

21

Drug for central diabetes insipidus

Desmopressin

22

Drugs for SIADH, hyponatremia?

Conivaptan (ADH antagonists)

23

Diuretics that cause acidosis? Alkalosis?

Acetazolamide and spironolactone- acidosis
Furosemide and hydrochlorothiazide - alkalosis

24

Site of action of carbonic anhydrase inhibitors

PCT