NSAIDs, DMARDs, Gout Flashcards Preview

Pharmacology 2 > NSAIDs, DMARDs, Gout > Flashcards

Flashcards in NSAIDs, DMARDs, Gout Deck (38):
1

Tx for kawasaki disease

Aspirin

2

Dosage range where aspirin follows first order elimination kinetics

3

Dosage where aspirin has antipyretic and analgesic effects

300-2400 mg/d

4

Dosage of aspirin for anti-inflammatory effect

2400-4000 mg/d
Follows zero order elimination kinetics

5

Toxic and lethal doses of aspirin?

Toxic dose: 150 mg/kg
Lethal dose: 30 g

6

Only IV NSAID

Ketorolac, use restricted to 72 hr

7

For closure of PDA

Indomethacin

8

COX 2 selective NSAIDs

Celecoxib
Etoricoxib
Parecoxib
Rofecoxib
Valdecoxib

9

COX 3 inhibitor, weak COX 1 and COX 2 inhibitor

Paracetamol
Acetaminophen
Phenacetin

10

Antidote for paracetamol

N-acetylcysteine

11

Cytotoxic intermediate of paracetamol

N-acetyl-p-benzoquinoneimine (NAPQI)

12

Toxic and lethal doses of paracetamol

TD: 150 mg/kg
LD: 15 g

13

Inhibits AICAR transformylase and thymidylatr synthetase

Methotrexate

14

DMARD of first choice to treat RA

Methotrexate

15

Binds to TNF -alpha, preventing activation of TNF-alpha receptor

Infliximab
Adalimumab
Etanercept

16

One of its SE is reactivation of latent TB

Infliximab

17

DMARD, Anti-malarial drug Safe for pregnant women

Chloroquine

18

SE of cyclophosphamide. Rescue agent?

Hemorrhagic cystitis, Mesna

19

Causes reversible infertility in men

Sulfasalazine

20

Nonselective, irreversible COX1 and COX2 inhibitor

Aspirin

21

Inhibits microtubule assembly

Colchicine

22

Commonly used replacement for colchicine in initial treatment of gout

Indomethacin

23

Why is aspirin not used in gout?

Due to its renal retention of uric acid at low doses

24

Uricosuric agent

Probenecid

25

MOA of probenecid

Compete with uric acid for reabsorption in the proximal tubules

26

MOA of allopurinol

Active metabolite irreversibly inhibits xanthine oxidase and lowers production of uric acid

27

1st line treatment for chronic gout, tumor lysis syndrome

Allopurinol

28

Inhibits metabolism of mercaptopurine and azathioprine

Allopurinol

29

MOA of Febuxostat

Nonpurine reversible inhibitor of xanthine oxidase

30

Inhibits microtubule assembly

Colchicine

31

Commonly used replacement for colchicine in initial treatment of gout

Indomethacin

32

Why is aspirin not used in gout?

Due to its renal retention of uric acid at low doses

33

Uricosuric agent

Probenecid

34

MOA of probenecid

Compete with uric acid for reabsorption in the proximal tubules

35

MOA of allopurinol

Active metabolite irreversibly inhibits xanthine oxidase and lowers production of uric acid

36

1st line treatment for chronic gout, tumor lysis syndrome

Allopurinol

37

Inhibits metabolism of mercaptopurine and azathioprine

Allopurinol

38

MOA of Febuxostat

Nonpurine reversible inhibitor of xanthine oxidase