Hyperlipidemia Flashcards Preview

Pharmacology 2 > Hyperlipidemia > Flashcards

Flashcards in Hyperlipidemia Deck (27):
1

Drugs most effective at lowering LDL cholesterol

statins, resins, ezetimibe, niacin

2

Inhibits HMG-CoA Reductase

Statins

3

MOA of Simvastatin

reversible competitive inhibitor of HMG-CoA reductase

4

Drugs most effective at lowering TG and VLDL and raising HDL

niacin, rates

5

MOA of statins

reversible competitive inhibitor of HMG-CoA reductase

6

Why are statins used in CAD?

for stabilization of atherosclerotic plaques

7

MOA of Cholestyramine

binds bile acids

8

Bile-acid binding resins

Cholestyramine, Colesevelam, colestipol

9

SE of Resins

Constipation, Bloating, Gritty taste, malabsorption (vit K and folate)

10

MOA of Ezetimibe

selective inhibitor of NOC1L1 tansporter, decreasing intestinal absorption of cholesterol and other phytosterols

11

Cholesterol analog

Sitosterol - decrease interstinal absorption of cholesterol and other phytosterols

12

MOA of Niacin

decreases VLDL synthesis and LDL cholesterol concentrations, increases HDL cholesterol

13

SE of Niacin

Flushing, pruritus, rashes, acanthosis nigricans, etc...Pre-treat with Aspirin to reduce flushing

14

MOA of Gemfibrozil

Activates PPAR-alpha proteins and increases expression of lipoprotein lipase and apoA-I, apoA-II, lowers TGs, Increases HDL

15

Ligands for peroxisome proliferator-activated receptor alpha protein

Fibrates

16

MOA of Gemfibrozil

Activates PPAR-alpha proteins and increases expression of lipoprotein lipase and apoA-I, apoA-II, lowers TGs, Increases HDL

17

Fibrates examples

Gemfibrozil, fenofibrate, bezafibrate

18

SE of Statin + Fibrate

Increased risk of myopathy and rhabdomyolysis

19

DOC for hypertriglyceridemia

Fibrates

20

SE of Statin + Fibrate

Increased risk of myopathy and rhabdomyolysis

21

DOC for High LDL

statins

22

DOC for low HDL

Niacin

23

DOC for High LDL

statins

24

Potentiates effects of antihypertensives (vasodilators, ganglion blockers)

Niacin

25

Reduces hormone-sensitive lipase activity in adipose tissues

Niacin

26

Also used in digitalis toxicity

cholestyramine

27

avoid in patients with diverticulitis

cholestyramine